摘要
总结了不同抑制剂对淀粉样蛋白聚集及纤维化的抑制作用,主要介绍了金属配合物作为淀粉样蛋白抑制剂的研究,并概述了淀粉样蛋白相互作用体系的热力学研究进展.
This review summarized different kinds of inhibitors that affect the aggregation and fibrillation of amyloid proteins. The metal complexes were optimized as potential and effective inhibitors of amyloid proteins. Moreover, the interaction systems of amyloid proteins were also generalized in the aspect of thermodynamics studies.
出处
《中国科学：化学》
CAS
CSCD
北大核心
2014年第6期822-830,共9页
SCIENTIA SINICA Chimica
基金
中国人民大学科学研究基金(中央高校基本科研业务费专项资金资助)项目(14XNH059)支持
关键词
淀粉样蛋白
金属配合物
聚集
热力学
amyloid proteins, metal complex, aggregation, thermodynamics
