摘要
目的探讨甲胎蛋白(AFP)、谷氨酰转移酶(GGT)和腺苷脱氨酶(ADA)在肝癌患者中的临床意义。方法随机选取肝癌患者、良性肝病患者及健康体检者(正常对照)各40例,并分别检测其血清中AFP、GGT及ADA含量,比较各组间的差异,并比较三种指标单独或联合检测对肝癌诊断的敏感性及特异性。结果血清AFP、GGT及ADA的含量在肝癌患者组较良性肝病组及正常对照组明显升高,其差异具有显著性(P<0.05)。对肝癌的临床诊断:单项检测AFP、GGT及ADA敏感性分别为80%、78%、72%,特异性分别为89%、76%、90%;三项联合检测的敏感性为91%,特异性为73%。结论三项指标的联合检测提高了对肝癌诊断的敏感性,更有利于肝癌的早期临床诊断。
Objective To investigate clinical significance of serum AFP, GGT and ADA in the diagnosis of liver cancer. Methods The levels of serum AFP,GGT and ADA were detected in 40 cases of liver cancer,40cases of benign liver diseases and 40 cases of normal controls, and the differences were analyzed between the three groups.The sensitivity and specificity of the three indacators （alone or combined） were also evaluated in the diagnosis of liver cancer. Results The level of serum AFP, GGT and ADA in liver cancer group were siginificant higher than that in the benign liver disease group and normal controls （P〈0.05）. The detection sensibility of AFP, GGT and ADA in liver cancer diagnosis were 80%, 78%, 72 % respectively, and the specificity were 89%, 76%, 90% separately. The sensibility and specificity of joint detection of AFP, GGT and ADA were 91% and 73% respectively. Conclusion The combined detection of three indicators improved the diagnostic sensibility, which will be conducive to improving the early diagnosis of liver cancer.
出处
《菏泽医学专科学校学报》
2014年第2期20-21,24,共3页
Journal of Heze Medical College
