摘要
目的了解脑梗塞住院患者下呼吸道感染病原菌的种类及耐药情况,为临床合理用药提供依据。方法通过回顾性调查,对某医院住院脑梗塞患者下呼吸道感染病原菌分布及耐药情况进行调查与分析。结果调查期间从住院脑梗塞下呼吸道感染患者送检标本中共检出病原菌213例,其中革兰阴性杆菌占77.93%,真菌占20.66%,革兰阳性球菌占1.41%。革兰阴性杆菌中以铜绿假单胞菌、肺炎克雷伯菌和鲍曼不动杆菌检出比例较高,构成优势菌群。铜绿假单胞菌中以多重耐药菌株居多,只对氨基糖苷类抗生素和多粘菌素B有较好的敏感性。产超广谱β-内酰胺酶(ESBLs)的肺炎克雷伯菌的检出比例也比较高。结论该医院住院神经外科脑梗塞患者下呼吸道感染以多重耐药的铜绿假单胞菌为主,临床应慎用碳青霉烯类药物,应加强耐药菌监测和药敏试验。
Objective To investigate the species and antibiotic resistance of pathogens from hospitalized patients with cerebral infarction infected on lower respiratory tract, so as to provide scientific basis for clinical rational medication. Meth- od Through the retrospective investigation, the species and antibiotic resistance of pathogens from hospitalized patients with cerebral infarction infected on lower respiratory tract were analyzed. Results The main pathogenic bacteria from the 213 isolated pathogen strains was the Gram negative bacilli （77.93 % ）, fungi （20.66%）, and the Gram positive cocci （ 1. 41% ）. The Gram negative bacilli with higher separation rate were Pseudomonas aeruginosa, Klebesiella pneumonia, Acine- tobacter baumannii, and they constituted a dominant flora. Pseudomonas aeruginosa had a high resistance to several kinds of antibiotics, and just had better sensitivity to Aminoglycoside antibiotics and Polymyxin B; Of the Klebesiella pneumonia, ESBLs（ ＋ ） also had a high separation rate. Conclusion The major cause of bacterial infection in hospitalized patients with cerebral infarction infected on lower respiratory tract in Neurosurgery is the multi - drug resistant Pseudomonas aerugi- nosa. Clinical should be careful of Carbapenems use; the supervision and drug susceptibility testing of drug resistance should be strengthened.
出处
《中国消毒学杂志》
CAS
北大核心
2014年第6期595-597,共3页
Chinese Journal of Disinfection
关键词
脑梗塞患者
下呼吸道感染
病原菌
多重耐药
cerebral infarction patients
lower respiratory tract infections
pathogens
multi - drug resistant
