摘要
目的:研究PTEN与PIK3-Akt通路在子宫内膜癌中的表达及临床意义。方法:采用免疫组化技术检测正常子宫内膜组织(24例)、子宫内膜样腺癌组织(55例)及子宫内膜浆液性癌组织(26例)中PTEN、P13Kp110α及p-AKTSer473的表达情况,分析其表达与组织病理参数的关系。结果:免疫组化结果显示:子宫内膜癌的PTEN表达缺失率,P13Kp110α及p-AKTSer473表达阳性率均高于正常子宫内膜组织,且正常子宫内膜组织与子宫内膜样腺癌组织比较有统计学意义(P<0.05);随着肌层浸润深度增加,PTEN表达缺失率增加(P<0.05)。结论:PTEN的表达缺失及P13Kp110α与p-AKTSer473的表达可能与子宫内膜癌的发生发展有关,尤其是在子宫内膜样腺癌的发生发展机制中占重要地位。
Objective： To study the expression of PTEN, PI3K-Akt signal pathway and their clinical significance in endometrial cancer. Methods： Immunohistochemistry technology was used to detect the expression of PTEN, P13Kp110α and p-AKTSer473 in normal endometrial tissues （24 cases）, endometrial adenocarcinoma tissues （55 cases） and endometrial serous carcinoma tissues（26 cases）. The relationship between the expression and the pathological parameters of tissues were analyzed. Results： Immunohistochemistry showed： The negative expression of PTEN and the positive expression of P13Kp110α and p-AKTSer473 in endometrial cancer tissues were higher than that in normal endometrial tissues, statistically significant differences were found in the comparison of normal endometrial tissues and endomettrial adenocarcinoma tissues （P〈0.05）; negative expression of PTEN increased with the increase of muscular layer infiltration depth （P〈0.05）.Conelusion： The negative expression of PTEN and the positive expression ofP13Kp110α and p-AKTSer473 might be related with the occurrence and development of endometrial cancer, especially in the occurrence and development of endometrial adenocarcinoma.
出处
《现代生物医学进展》
CAS
2014年第19期3699-3702,共4页
Progress in Modern Biomedicine
