摘要
目的探讨原发肿瘤切除和靶向治疗在Ⅳ期乳腺癌治疗中的作用。方法收集Ⅳ期乳腺癌患者300例,按照不同的治疗方案分为试验组和对照组,每组150例。所有患者均采用改良根治术进行治疗,试验组患者加用对甲苯磺酰胺注射液进行靶向治疗。结果试验组和对照组患者的有效率分别为73.3%和46.7%,差异有统计学意义（P〈0.05）。两组患者的主要不良反应为Ⅰ~Ⅱ级的骨髓抑制、消化道反应和呕吐等,两组间差异无统计学意义（P〉0.05）。试验组和对照组患者的1年生存率分别为90.7%和73.3%,两组间差异有统计学意义（P〈0.05）。结论原发肿瘤改良根治术联合靶向药物治疗Ⅳ期乳腺癌能够提高疗效和生存时间,降低不良反应的发生。
Objective To investigate the roles of primary tumor resection combined with targeted therapy for treating stage Ⅳ breast cancer. Methods A total of 300 cases of stage IV breast cancer were collected and divided into observed group and control group according to different treatment regimens. All patients were treated with modified resection. The observed group additionally received targeting therapy with toluene sulfonamide injection. Results The response rate of observed group and control group were 73.3% and 46. 7%, respectively. The differences between the two groups was statistically significant （P 〈 0. 05 ）. The major adverse reactions were grade I ~ lI bone marrow suppression, gastrointestinal reactions and vomiting. The difference was not statistically significant （ P 〉 0. 05 ）. The 1-year survival rates of the observed group and control group were 90. 7% and 73.3% , respectively. The differences between the two groups were statistically significant （P 〈 0. 05）. Conclusion Primary tumor resection combined with targe- ted drug therapy for treating stage Ⅳ breast cancer can not only improve the prognosis efficacy and survival but also reduce the occurrence of adverse reactions.
出处
《中国肿瘤临床与康复》
2014年第6期700-702,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
原发肿瘤切除
靶向治疗
乳腺肿瘤
不良反应
Primary tumor resection
Targeted therapy
Breast neoplasms
Adverse reactions
