期刊文献+

抗结核药物治疗致Stevens-Johnson综合征患儿的诊治及护理策略

原文传递
导出
摘要 Stevens-Johnson 综合征(Stevens-Johnson syndrome,SJS),又称为重症多形红斑,是一种严重的累及全身皮肤和黏膜的罕见疾病.SJS所致的皮肤损害呈对称性,表现为水肿性红斑、水泡、大疱、血疱和淤斑等,广泛分布于身体各部位,尤其以口腔、鼻、咽、眼、尿道、肛门和呼吸道等黏膜损害最为严重,少数病情严重者可因继发感染或合并心脏、肾脏并发症而导致死亡.Roujeau等的文献报道,SJS发生率为0.001%,病死率为10%,且SJS导致的后遗症十分严重,特别是对视觉的损害,可以影响30%~70%存活者,临床上一旦发现SJS,应立即停用可疑的致病药物,并静脉注射大剂量免疫球蛋白或免疫抑制剂[甲泼龙 (methylprednisolone).
出处 《中华妇幼临床医学杂志(电子版)》 CAS 2014年第3期102-104,共3页 Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)
  • 相关文献

参考文献5

二级参考文献29

  • 1耿建华,刘兴国.甲泼尼龙治疗重型渗出性多形性红斑20例[J].实用儿科临床杂志,2006,21(4):242-243. 被引量:6
  • 2Hung SI, Chung WH, Jee SH, et al. Genetic susceptibility to carbamazepine - induced cutaneous adverse drug reactions [ J ]. Pharmacogenet Gertomics,2006,16 (4) : 297 - 306.
  • 3Tassaneeyakul W,Tiamkao S, Jantararoungtong T,et al. Association between HLA - B * 1502 and carbamazepine - induced severe cutaneous adverse drug reactions in a Thai population [ J ]. Epilepsia, 2010,51 (5) :926 -930.
  • 4Htmg SI, Chtmg WH, Liou LB,et al. HLA - B * 5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol [ J]. Proc Natl Acad Sci USA,2005,102( 11 ):4134-4139.
  • 5I Kaniwa N ,Saito Y ,Aihara M,et al. HLA - B locus in Japanese patients with anti - epileptics and allopurinol - related Stevens - Johnson syndrome and toxic epidermal necrolysis [ J ]. Pharmacogenomics, 2008,9 (11) :1617 -1622.
  • 6Tassaneeyakul W,Jantararoungtong T,Chen P,et al. Strong association between HLA - B * 5801 and allopurinol - induced Stevens - Johnson syndrome and toxic epidermal necrolysis in a Thai population [ J ]. Pharmacogenet Genomics ,2009,19(9 ) :704 - 709.
  • 7Lonjou C,Borot N,Sekula P,et al. A European study of HLA -B in Stevens- Johnson syndrome and toxic epidermal necrolysis related to five high - risk drugs [ J ]. Pharmacogenet Genomics, 2008,18 ( 2 ) : 99 - 107.
  • 8Wu XT, Hu FY, An DM,et al. Association between earbamazepine -induced cutaneous adverse drug reactions and the HLA - B * 1502 allele among patients in central China[ J ]. Epilepsy Behav ,2010,19 (3) :405 - 408.
  • 9Locharernkul C, Loplumlert J, Limotai C,et al. Carbamazepine and phenytoin induced Stevens - Johnson syndrome is associated with HLAB * 1502 allele in Thai population [ J ]. Epilepsia. 2008,49 ( 12 ) : 2087 - 2091.
  • 10Lonjou C, Thomas L, Borot N, et al. A marker for Stevens - Johnson syndrome ethnicity matters[ J ]. Pharmacogenomics J,2006,6(4) :265 - 268.

共引文献46

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部