摘要
目的:分析stathmin 1和HIF1在宫颈上皮内瘤变(CIN)和鳞癌中的表达,探讨其临床意义。方法:采用免疫组织化学技术检测stathmin 1和HIF1在宫颈鳞状上皮、上皮内瘤变和鳞癌中的表达,分析其与临床病理指标的相关性。结果:Stathmin 1在宫颈鳞状上皮、CINⅠ、CINⅡ、CINⅢ、鳞癌中的阳性表达率为20.4%、20.7%、21.9%、72.7%和84.3%,CINⅢ级与宫颈鳞癌中stathmin 1表达率较宫颈正常组、CINⅠ级组、CINⅡ级组显著增高。HIF1在正常宫颈鳞状上皮、CINⅠ、CINⅡ、CINⅢ、鳞癌中的阳性表达率为17.6%、15.9%、29.3%、73.5%和79.5%,CINⅢ级组与宫颈鳞癌组中HIF1表达率较宫颈正常鳞状上皮组、CINⅠ级组、CINⅡ级组显著增高。Stathmin 1和HIF1在Ⅲ-Ⅳ期宫颈癌中的表达显著高于Ⅰ-Ⅱ期,两者表达之间有关联。结论:Stathmin 1和HIF1表达与宫颈癌的发生和演进有关。
Objective： To evaluate the expression of stathmin 1 and HIF1 protein expression in pre malignant and neoplastic lesions by immunohistochemistry in uterine cervix, and its clinical significance. Methods： Immunohistochemical technique was applied to detect protein expression and their correlation to clinicopathological index. Results： The positive expression of stathmin 1 in normal cervical squamous epithelium, CIN Ⅰ , CIN Ⅱ , CINⅢ and squamous cell carcinoma were 20.4%, 20.7%, 21.9%, 72.7% and 84.3% respectively, stathmin 1 positive rate of CINⅡ and cervical carcinoma tissues were higher than those of normal epithelium, CINⅠ , CINⅡ tissues and the differences were statistically significant（P〈0.01）. The positive rate of HIF1 in normal cervical squamous epithelium, CIN Ⅰ , CIN Ⅱ , CINⅢ and squamous cell carcinoma were 17.6 %, 15.9%, 29.3 %, 73.5% and 79.5% respectively. HIF1 positive rate of CIN Ⅲ and cervical carcinoma tissues were higher than those of normal epithelium, CIN, CIN Ⅱ tissues and the differences were statisti cally significant（P〈0.01）. Expression rate of stathmin 1 and HIF1 in stage Ⅲ and Ⅳ cervical car cinoma were significantly higher than that in stage Ⅰ and Ⅱ. Correlationship existed between stath min 1 and HIF1 expression. Conclusion：stathmin 1 and HIF1 expression were related to the devel opment and progression of cervical carcinoma.
出处
《华夏医学》
CAS
2014年第1期13-17,共5页
Acta Medicinae Sinica
