摘要
目的:探讨分析MICA外显子5多态性与成人迟发自身免疫型糖尿病(LADA)的相关性情况。方法:选取2010年5月-2013年8月收治的LADA患者33例(LADA组),另选取同期收治的2型糖尿病患者35例(T2DM组)及正常体检者40例(NC组),对比观察三组患者MICA外显子5多态性的差异。结果:LADA组患者MICA第5外显子中A5.1等位基因的频率相比NC组明显增高,两组比较差异有统计学意义(P<0.05)。而其他等位基因型分布与NC组比较差异均无统计学意义(P>0.05);T2DM组患者MICA第5外显子等位基因多态性分布与NC组比较差异均无统计学意义(P>0.05)。结论:LADA患者的MICA基因外显子5多态性与正常人有异,其中等位基因A5.1与LADA发病存在较密切相关性,是LADA的重要危险因素,也可视为LADA的一种遗传性指标。
Objective：To investigate the correlation situation of the MICA polymorphism of fifth exon and late onset autoimmune diabetes in adult（LADA）. Method：Thirty-three cases of LADA patients（LADA group） from May 2010 to August 2013,35 patients with type 2 diabetes（T2DM group） and 40 cases of normal controls（NC group） were selected. The three groups in MICA exon 5 polymorphism difference were observed and compared. Result：Gene MICA fifth exon A5.1 promoter allele frequency in LADA group was significantly higher than NC group（P〈0.05）,while the other allele distribution had no significant difference between NC group and LADA group（P〉0.05）. Gene MICA fifth exon A5.1 promoter allele frequency in T2DM group was no significantly difference with NC group（P〉0.05）. Conclusion：LADA patients with gene MICA exon 5 polymorphism are different with normal people,the allele A5.1 and LADA disease are closely related,which is an important risk factor of LADA and can be regarded as a genetic marker in LADA.
出处
《中外医学研究》
2014年第16期36-37,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
