摘要
目的：观察肾康注射液对老年急性肾损伤患者的临床疗效。方法：选择42例老年急性肾损伤患者,随机分为对照组和治疗组,其中对照组21例,治疗组21例。对照组予常规内科综合治疗,治疗组在对照组基础上每日予肾康注射液60~100ml静滴,7天为一疗程。观察两组患者治疗前、后血清肌酐（Scr）、血胱抑素C（CysC）水平及急性生理与慢性健康状况评分Ⅱ（APACHEⅡ评分）,并进行临床疗效评价,比较两组总有效率。结果：两组患者治疗后Scr、血CysC水平及APACHEⅡ评分较治疗前均有明显降低（P〈0.05）,而且治疗组比对照组Scr、血CysC水平及APACHEⅡ评分降低更明显（P〈0.05）;治疗组总有效率显著高于对照组（P〈0.05）。结论：肾康注射液可改善老年急性肾损伤患者的肾功能,促进肾功能早期恢复,改善患者症状,降低病死率。
Objective：To investigate the clinical effects of Shenkang Injection in the treatment of elderly patients with acute kidney injury. Methods ：42 elderly patients with acute kidney injury were chosen and randomly divided into the treatment group （ 21 cases） and the control group （21 cases）, the control group were treated by regular combination therapy,while the treatment group were given by 60 - 100m1 Shenkang Injection per day on the basis of routine therapies ,a course of treatment for 7 days. The serum creatlnine（Scr） ,blood cystatin C （CysC） ,acute physiology and chronic health evaluation score n （ APACHE Ⅱ score） were examined and compared before and after 7 days treatment. The clinical effects were evaluated and the overall effective rate were compared between the two groups. Results： After treatment the levels of Scr and CysC, and the APACHE Ⅱ score significantly decreased in the two groups （ P 〈 0.05 ）, while the decreases of Scr, CysC and the APACHE n score in the treatment group were significianfly more than those in the control group （ P 〈 0.05 ）. The overall effective rate of the treatment group was significianfly better than that of the control group（ P 〈 0.05 ）. Conclusion： Sbenkang Injection has obvious effect on improvement of kidney function in elderly patients with acute kidney injury. It can promote recovery of renal function, relieve the clinical symptom of the patients with acute kidney injury and decrease the mortality.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2014年第1期136-139,共4页
Pharmacology and Clinics of Chinese Materia Medica
基金
安徽中医学院临床科学研究基金项目(2012LC1-029B)
关键词
肾康注射液
急性肾损伤
胱抑素C
Sbenkang Injection（肾康注射液）
acute kidney injury
cystatin C
