摘要
急性肾损伤是一种ICU患者中常见的疾病,致死率较高,当合并肺损伤时,致死率显著提高,可达到80%。急性肾损伤可导致全身体液灌注量增加,血浆渗透压升高进而引起肺水肿和急性呼吸衰竭。同时,炎症反应,氧化应激,细胞凋亡和可溶性调节因子代谢异常等也可能参与急性肾损伤诱导的肺损伤。对急性肾损伤诱导肺损伤的临床认识和可能发病机制的研究,将有助于临床疾病的治疗和死亡率的降低,同时也将有助于对其它肾脏疾病发病机制的认识。
Acute kidney injury（AKI）is a common disease with high mortality rate in the department of ICU. When AKI combined with acute lung injury（ALI）, the mortality rate may be higher and reach 80%. Acute kidney injury can lead to increased systemic perfusion fluids and elevated plasma osmolality, and thus cause pulmonary edema and acute respiratory failure. It was helpful for treatment and lower mortality rate if we could know more about clinical features of AKI-induced AIL and its pathogenesis.
出处
《中国处方药》
2014年第3期127-128,共2页
Journal of China Prescription Drug
关键词
急性肾损伤
急性肺损伤
发病机制
Acute kidney injury（ AKI）
Acute lung injury（ALI）
Pathogenesis
