摘要
目的:研究舒肝顺气丸对胃溃疡、反流性食管炎模型鼠的保护作用。方法:通过对利血平、无水乙醇、幽门结扎、水应激复制鼠胃溃疡模型;对贲门切开联合半结扎幽门复制大鼠反流性食管炎模型。5个实验均分为正常对照组、模型组、舒肝健胃丸组、化学药对照(西咪替丁/西沙比利)组与舒肝顺气丸高、中、低剂量组。检查胃溃疡模型鼠胃溃疡病变程度,计算溃疡指数或溃疡发生率;测定反流性食管炎模型大鼠血管活性肠肽、血浆胃动素和血清胃泌素含量。结果:与胃溃疡模型组(利血平/无水乙醇导致/水应激)比较,舒肝顺气丸高、中剂量组鼠溃疡指数降低,差异有统计学意义(P<0.01或P<0.05);与胃溃疡模型组(幽门结扎)比较,舒肝顺气丸高、中剂量组大鼠溃疡发生率降低,差异有统计学意义(P<0.01或P<0.05);与反流性食管炎模型组比较,舒肝顺气丸高、中剂量组大鼠血管活性肠肽含量减少,血浆胃动素和血清胃泌素含量增加,差异有统计学意义(P<0.01或P<0.05)。结论:舒肝顺气丸具有较强的改善功能性消化不良症状、治疗胃溃疡的作用。该研究为舒肝顺气丸的再评价及临床应用提供了药理学依据。
OBJECTIVE： To study the protective effect of Shugan shunqi pills on gastric ulcer and reflux esophagitis model rats. METHODS： The gastric ulcer model was induced by reserpine, absolute ethanol, pyloric ligation and water immersion stress method; the reflux esophagitis was induced by cardiotomy and half pyloric ligation. The experimental rats were divided into blank control group, model control group, Shugan jianwei pill group, chemical drug （cimetidine / cisapride） group, Shugan shunqi pill high-dose, medium-dose and low-dose groups. The degree of greater curvature ulcer on gastric ulcer model mice/rats of was detect- ed, and gastric ulcer index was calculated, rat plasmamotilin and serum gastrin content on reflux esophagitis model of vasoactive intestinal peptide was determined. RESULTS： Compared with gastric ulcer group （reserpine, absolute ethanol and water immersion stress method）, gastric ulcer index was decreased in Shugan shunqi pill high-dose and medium-dose groups; there was statistical significance （P〈 0.01 or P〈 0.05）. Compared with gastric ulcer group （ pyloric ligation method）.The incidence of ulcers was decreased in Shugan shunqi pill high-dose and medium-dose groups; there was statistical significance （P〈0.01 or P〈0.05）.Compared with reflux esophagitis model group, the content of vasoactive intestinal peptide in rats was decreased in Shugan shunqi pill high-dose and medium-dose groups, while the contents of plasma motilin and serum gastrin were increased; there was statistical significance （P〈0.01 or P〈0.05）. CONCLUSIONS： Shugan shunqi pills possess beneficial effect to improve functional dyspepsia symptoms and treat gastric ulcer, which provides pharmacological support for re-evaluation and clinical application of Shugan shunqi pills.
出处
《中国药房》
CAS
CSCD
2014年第23期2121-2124,共4页
China Pharmacy
关键词
舒肝顺气丸
胃溃疡
反流性食管炎
Shugan shunqi pills
Gastric ulcer
Reflux esophagitis
