摘要
目的：研究特异性免疫治疗前后变应性鼻炎患者血清白细胞介素IL-6、IL-8、IL-12的变化及意义。方法：用酶联免疫吸附试验ELISA检测健康体检者（对照组）19名，变应性鼻炎（鼻炎组）70例特异性免疫治疗前后的血清IL-6、IL-8、IL-12及总免疫球蛋白ETIgE水平。结果：鼻炎组特异性免疫治疗前与对照组相比，IL-6、IL-8、IL-12均明显升高，P ＜0．01；特异性免疫治疗后与治疗前相比，IL-8显著降低 P ＜0．01，IL-6明显降低 P ＜0．05，IL-12虽有降低，但无显著性差异，P ＞0．05。特异性免疫治疗前IL-6、IL-8与TIgE呈正相关，IL-12与TIgE呈负相关。结论：特异性免疫治疗使变应性鼻炎患者IL-6、IL-8、IL-12的分泌趋于正常，提示特异性免疫治疗有可能通过改善机体的免疫功能而发挥作用。
Objective To study influence of specific immunotherapy on serum IL-6 IL-8 and IL-12 in allergic rhinitis． Methods Serum IL-6 IL-8 IL-12 and total IgETIgE were measured by ELISA before and after immunotherapy in 70 allergic rhinitis patients and in 19 healthy controls． Results Serum IL-6 IL-8 and IL-12 were significantly higher in patients with allergic rhinitis than those in healthy controlsP ＜0．001 and were signifcantly reduced after immunotherapyP ＜0．05 except for IL-12P ＞0．05． Serum IL-6 and IL-8 showed positive correlation with TIgE while IL-12 had negative correlation with TIgE． Conclusion Specific immunotherapy tends to normalize the serum IL-6 IL-8 and IL-12 in patients with allergic rhinitis probably via improving body immune function．
出处
《新医学》
北大核心
2001年第3期147-148,共2页
Journal of New Medicine
基金
深圳市科技局立项课题! 编号9811
关键词
白细胞介素
变应性鼻炎
免疫球蛋白
免疫疗法
Sensitivity and specificity Immunity Interleukin Rhinitis，allergic Perennial Immunoglobulins
