摘要
目的 :从分子遗传水平对 2型糖尿病 (2 - DM)和冠心病患者进行多基因联合研究 ,以探讨其内在的相互联系。方法 :2 81例病例均进行血管紧张素转换酶 (ACE)基因、血管紧张素肽原 (ATN)基因、血浆纤溶酶原激活物抑制因子 (PAI- 1)基因多态性测定 ,并进行 L ogistic多元回归分析。结果 :在 2 - DM组 ,冠心病者 PAI- 1基因型频率及等位基因频率明显变化 (P<0 .0 5 ,P<0 .0 1) ,ATN基因型频率及等位基因频率明显变化 (P<0 .0 5 ,P<0 .0 1) ;在非糖尿病组 ,ATN基因型频率有明显的统计学差异 (P<0 .0 5 ) ;L ogistic多元回归分析发现 ,冠心病和年龄、肥胖、PAI- 1基因、ATN基因有显著关系。结论 :ATN基因多态性可能是冠心病的危险因素 ,PAI- 1基因突变可能主要是 2 -
Objective:To explore the relationship between type 2 DM and coronary heart disease (CHD) with mutiple genes analysis.Methods:The polymorphisms of the angiotensin-converting enzyme(ACE) gene, angiotens inogen (ATN)gene,plasminogen activator inhibitor-1 (PAI-1)gene in 281 cases we re analyzed. Results:In DM groups, the frequencies of PAI-1 genotype and 4G allele in CHD patients were increased(P<0.05,P<0.001,respectively ).And in non-DM group, the frequencies of ATN genotype and 4G allele in CHD pat ients were also increased(P<0.05,P<0.001, respectively). In non-DM grou p, the frequencies of ATN genotype in CHD patients were different from non-CHD subjects(P<0.05). In the mutilple regression analyses, CHD were related to a ge, obesity,and PAI-1 gene and ATN gene.Conclusion:Polymorphism of ATN gene may be the rish factor for CHD and PAI-1 gene mutation may be the essential risk factor of CHD with DM.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2001年第2期95-98,共4页
Journal of Nanjing Medical University(Natural Sciences)
