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CRP、qPCR、组织病理学冰冻和石蜡切片评价在诊断假体关节感染中的应用 被引量:1

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摘要 假体周围关节感染(periprosthetic joint infection,PJI)是髋关节和膝关节手术最严重的并发症,一旦发生,常常给患者造成灾难性后果,而且长期抗感染及多次手术将极大地增加患者经济负担并影响关节功能[1]。PJI 在诊断方面仍然非常困难[2],常规细菌培养在很长一段时间被视为诊断 PJI的“金标准”。然而,最近的研究表明,这种方法的准确性有限,尤其在低度感染时,常引起假阴性结果[3]。所以迫切需要一个更准确的诊断方法。唐浩和周一新[4]报道,如果符合以下标准,可以认为 PJI 明确存在:①存在与假体相通的窦道;②受累人工关节的2处假体周围组织或关节液标本中分离出同一病原体;③满足以下6条中的4条:红细胞沉降率(ESR)或 C 反应蛋白(CRP)水平升高、滑膜白细胞计数升高、滑膜中性粒细胞(PMN)百分比升高、受累关节出现化脓表现、假体周围组织或关节液标本中1次培养分离出细菌、400倍放大率下,假体周围组织的病理学分析在每高倍显微视野下发现大于5个 PMN。
出处 《中国医药生物技术》 2014年第3期225-227,共3页 Chinese Medicinal Biotechnology
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参考文献14

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二级参考文献13

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