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去唾液酸糖蛋白受体的研究现状 被引量：3

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摘要 去唾液酸糖蛋白受体（ asialoglycoprotein receptor ， ASGPR），也被称为肝细胞半乳糖/N-乙酰基葡糖胺受体，或者 Ashwell-Morell 受体[1]。它主要表达于肝窦状间隙的肝实质细胞表面，是第一个被发现的凝集素。由于它结合配体的钙离子依赖性，因此属于 C 型凝集素。ASGPR 能够介导去唾液酸化的糖蛋白被肝细胞内吞降解[2]。目前已知的ASGPR 的配体非常多，提示其在糖蛋白代谢、脂代谢、凋亡细胞降解、调节凝血、介导病毒进入细胞和自身免疫性炎症反应等多个生理环节均发挥着重要的作用[3]。
作者 张黎 黄维金 许雪梅 王佑春
机构地区 中国食品药品检定研究院艾滋病性病病毒疫苗室 中国医学科学院基础医学研究所 北京协和医学院基础学院生物物理及结构生物学系
出处 《中国医药生物技术》 2014年第3期214-218,共5页 Chinese Medicinal Biotechnology
基金 国家自然科学基金(81371830)
关键词 去唾液酸糖蛋白受体 RECEPTOR ASGPR 糖蛋白代谢 自身免疫性 细胞表面 细胞内吞 唾液酸化
分类号 R341 [医药卫生—基础医学]
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参考文献52

  • 1Gilbert Ashwell: sweet on science. Nat Med, 2008, 14(6):608.
  • 2Grevcai PK. The Ashwell-Morell receptor. Methods Enzymol, 2010, 479(2):23-41.
  • 3Rigopoulou El, Roggenbuck D, Smyk DS, et al. Asialoglycoprotein receptor (ASGPR) as target autoantigen in liver autoimmunity: lost and found. Autoimmun Rev, 2012, 12(2):260-269.
  • 4Weigel PH, Yik JH. Glycans as endoeytosis signals: the cases of the asialoglycoprotein and hyaluronan/chondroitin sulfate receptors. Biochim Biophys Acta, 2002, 1572(2-3):341-363.
  • 5Yik JH, Saxena A, Weigel PH. The minor subunit splice variants, H2b and H2c, of the human asialoglycoprotein receptor are present with the major subunit H1 in different hetero-oligomeric receptor complexes. J Biol Chem, 2002, 277(25):23076-23083.
  • 6Liu J, Hu B, Yang Y, et al. Anew splice variant of the major subunit of human asialoglycoprotein receptor encodes a secreted form in hepatocytes. PLoS One, 2010, 5(9):e12934.
  • 7Renz M, Daniels BR, Vlmosi G, et al. Plasticity of the asialoglycoprotein receptor deciphered by ensemble FRET imaging and single-molecule counting PALM imaging. Proc Natl Acad Sci U S A, 2012, 109(44):E2989-E2997.
  • 8Harris RL, van den Berg CW, Bowen DJ. ASGR1 and ASGR2, the genes that encode the asialoglycoprotein receptor (ashwell receptor), are expressed in peripheral blood monocytes and show interindividual differences in transcript profile. Mol Biol Int, 2012:283974.
  • 9Mu JZ, Fallon RJ, Swanson PE, et al. Expression of an endogenous asialoglycoprotein receptor in a human intestinal epithelial cell line, Caco-2. Biochim Biophys Acta, 1994, 1222 (3) :483 -491.
  • 10Sun P, Zheng J, She G, et al. Expression pattern of asialoglyeoprotein receptor in human testis. Cell Tissue Res, 2013, 352(3):761-768.

二级参考文献43

  • 1张宏娟,丁娅,张灿,沈健.O-羧甲基N-半乳糖化壳聚糖衍生物的设计、合成和表征[J].中国天然药物,2004,2(6):354-358. 被引量：8
  • 2Park EI,Mi Y,Unverzagt C,et al.The asialoglycoprotein receptor clears glycoconjugates terminating with sialic acid alpha 2,6 GalNAc[J].Proc Natl Acad Sci USA,2005,102:17125-17129.
  • 3Park EI,Manzella SM,Baenziger JU.Rapid clearance of sialylated glycoproteins by the asialoglycoprotein receptor[J].J Biol Chem,2003,278:4597-4602.
  • 4McVicker BL,Tuma DJ,Kubik JA,et al.The effect of ethanol on asialoglycoprotein receptor-mediated phagocytosis of apoptotic cells by rat hepatocytes[J].Hepatology,2002,36:1478-1487.
  • 5Owada T,Matsubayashi K,Sakata H,et al.Interaction between desialylated hepatitis B virus and asialoglycoprotein receptor on hepatocytes may be indispensable for viral binding and entry[J].J Viral Hepat,2006,13:11-18.
  • 6Saunier B,Triyatni M,Ulianich L,et al.Role of the asialoglycoprotein receptor in binding and entry of hepatitis C virus structural proteins in cultured human hepatocytes[J].J Virol,2003,77:546-559.
  • 7Li XF,Taki J,Kinuya S,et al.Asialoglycoprotein receptor concentration in tumor-bearing livers and its fate early after their sectorial resection[J].Ann Nucl Med,2003,17:489-493.
  • 8Casey CA,McVicker BL,Donohue TM Jr,et al.Liver asialoglycoprotein receptor levels correlate with severity of alcoholic liver damage in rats[J].J Appl Physiol,2004,96:76-80.
  • 9Ise H,Nikaido T,Negishi N,et al.Effective hepatocyte transplantation using rat hepatocytes with low asialoglycoprotein receptor expression[J].Am J Pathol,2004,165:501-510.
  • 10Khatri K,Rawat A,Mahor S,et al.Hepatitis B surface protein docked vesicular carrier for site specific delivery to liver[J].J Drug Target,2005,13:359-366.

共引文献26

同被引文献31

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二级引证文献18

中国医药生物技术
2014年 第3期

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