摘要
目的:探讨舒张性心力衰竭(diastolic heart failure,DHF)患者左房容积指数(left atrium volume index,LAVI)与N-末端脑钠肽前体(NT-pro brain natriuretic pepitide,NT-proBNP)之间的相关性。方法:选取65例DHF患者,按NYHA分级分为NYHAⅠ组、Ⅱ组、Ⅲ组、Ⅳ组,选择同期健康体检者40例作为对照组,分别测量每组LAVI值及血浆NT-proBNP水平,分析两者的相关性。结果:(1)LAVI的比较:DHF组患者LAVI值水平明显高于对照组,且随着心力衰竭程度的加重而升高。DHF组各组之间比较亦差异有统计学意义;(2)NT-proBNP的比较:DHF组患者NT-proBNP浓度水平明显高于对照组(P<0.01),且随着心力衰竭程度的加重而升高。DHF组组内比较差异有统计学意义(P<0.01);(3)相关性分析表明,DHF患者LAVI值与lgNT-proBNP水平与NYHA心功能分级之间正相关(r=0.763,P<0.05)。结论:DHF患者的LAVI水平与NT-proBNP浓度随着心力衰竭的严重程度而增加,它们是评价DHF患者舒张功能的较敏感指标,二者有较好的相关性。
Objective： To investigate the correlation between left atrium volume index（LAVI） and NT-proBrain natriuretic peptide（ NT- proBNP） in patients with diastolic heart failure（ DHF）. Methods ： We chosed 65 cases of DHF patients, according to the NYHA classification, they were divided into NYHA group Ⅰ, Ⅱ, Ⅲ, Ⅳ, and we enrolled the same period 40 healthy persons as control group. Each group was measured the level of plasma NT-proBNP and LAVI, we analyzed their correlation. Results： Comparison of LAVI：LAVI level of patients in DHF groups was significantly higher than that of control group, and it increased with increasing severity of diastolic heart failure. There was also difference among heart failure groups（P0.05）. Comparison of NT-proBNP：NT-proBNP level of patients in DHF groups was significantly higher than that of control group（P0.01）, and it increased with increasing severity of diastolic heart failure. There was significant difference among heart failure groups（P0.01）. Correlation analysis showed： patients with DHF, there was positive correlation between LAVI value and lgNT-proBNP level（r=0.763, P0.05）. Conclusion： The level of LAVI and NT-proBNP concentration in patients with DHF increased with the severity of heart failure, they were sensitive index to evaluate cardiac function in patients with DHF.
出处
《南通大学学报（医学版）》
2014年第2期111-113,共3页
Journal of Nantong University(Medical sciences)
关键词
舒张性心力衰竭
左房容积指数
N-末端脑钠肽前体
diastolic heart failure
left atrium volume index
NT-pro brain natriuretic peptide
