摘要
目的研究血小板膜糖蛋白和多项相关血液指标在脑梗死急性期患者体内的变化,探讨血小板活化在脑梗死发病与转归中的作用。方法应用流式细胞术(FCW)检测脑梗死急性期患者与健康对照组血小板膜GPⅡb/Ⅲa复合物和P-选择素。应用自动血液凝血分析仪测定脑梗死急性期患者与健康对照组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)。应用全自动血细胞分析仪测定脑梗死急性期患者与健康对照组血小板计数(PLT)、平均血小板体积(MPV)和血小板分布宽度(PDW)。结果脑梗死急性期患者血小板膜GPⅡb/Ⅲa复合物和P-选择素、PT、FIB、MPV和PDW均高于健康对照组(p<0.01);脑梗死急性期患者与健康对照组APTT的差异无统计学意义(p>0.05);脑梗死急性期患者外周血PLT较健康对照组降低(p<0.01)。结论血小板膜糖蛋白GPⅡb/Ⅲa复合物和P-选择素可作为表明血小板活化的敏感指标,在脑梗死的诊断和治疗中有着重要的意义。PT、FIB、MPV、PDW和PLT对脑梗死的诊疗有一定的提示作用。
Objective To study change of platelet membrane glycoprotein and multiple related blood indexes in patients with acute cerebral infarction.,in order to investigate the role of platelet activation in cerebral infarction and prognosis. Methods Detect platelet membrane glycoprotein Ⅱb /Ⅲa complex and P- selectin between patients with acute cerebral infarction group and normal control group by flow cytometry. PT,APTT and FIB were measured by automated coagulation analyzer. PLT,MPV and PDW were measured by automatic blood analyzer. Results The platelet membrane glycoprotein Ⅱb /Ⅲa complex and P- selectin,PT,FIB,MPV and PDW of patients with acute cerebral infarction groups were significantly higher than those in healthy control groups（ p 0. 01）. There was no significant difference in APTT among each group（ p 0. 05）. The PLT of patients with acute cerebral infarction groups were significantly lower than those in healthy control groups（ p 0. 01）. Conclusion The platelet membrane glycoprotein Ⅱb /Ⅲa complex and P- selectin maybe used as one sensitive index of platelet activation,it may play an important role in the the diagnosis and treatment of cerebral infarction. PT,FIB,MPV,PDW and PLT has a prompt significance in the the diagnosis and treatment of cerebral infarction.
出处
《现代医院》
2014年第5期69-71,共3页
Modern Hospitals
基金
东莞市医疗卫生科技计划一般项目(编号:20131051010003)
关键词
脑梗死
血小板活化
血小板膜GPⅡb
Ⅲa复合物
P-选择素
Cerebral Infarction
Platelet activation
Platelet membrane glycoprotein Ⅱb/Ⅲa complex
P-selectin
