摘要
目的:优选防己中粉防己碱和防己诺林碱的最佳提取工艺。方法:以总生物碱的含量和浸膏的率为考察指标,采用正交试验,考察提取溶媒的浓度、提取时间、提取次数和提取溶媒的用量对提取的影响,确定了防己中粉防己碱和防己诺林碱的最佳提取工艺。结果:最佳提取工艺条件是:以6倍量60%乙醇提取3次,每次1小时。结论:优选得到的提取工艺得率高,操作简便易行。
Objective： To optimize the extraction process of Fangchinoline and Tetrandrine in StephaniaTetrandra S. Moore by orthogonal design. Methods： The optimal extraction conditions,such as the concentration of extraction solvent,extraction time,extraction times and amount of solvent to material were investigated by orthogonal design; the content of the total alkaloids and Extract yield were the inspection index. Results： The optimal conditions for the extraction process were as follows,and took 60% alcohol as dissolving medium,extract 3 times,1 h / time. Conclusion： The extraction technology developed after optimization was a high efficiency and easier to operate.
出处
《中国药物评价》
2014年第2期79-81,85,共4页
Chinese Journal of Drug Evaluation
基金
"重大新药创制"科技重大专项(编号:2011ZX09201-201-10)资助项目
山东省科技发展计划--经典中药大品种阿胶技术升级
编号:2013G0031901
关键词
正交试验
粉防己碱
防己诺林碱
防己
Orthogonal experiment
Fangchinoline
Tetrandrine
Stephaniatetrandra S.Moore
