摘要
目的探讨高频振荡通气(HFOV)与常频机械通气(CMV)治疗重症新生儿胎粪吸入综合征(MAS)的临床疗效。方法将60例重症MAS患儿随机分为CMV组与HFOV组各30例,动态监测两组患儿48 h内的pH值、氧气分压(PaO2)、二氧化碳分压(PaCO2)、吸入氧浓度(FiO2)、氧合指数(OI)等变化情况,比较两组患儿的并发症及临床转归。结果两组患儿上机前(0 h)的pH值、PaO2、PaCO2、FiO2、OI差异均无统计学意义(P>0.05),上机后在2、12、24、48 h时间点上,差异均有统计学意义(P均<0.05);两组患儿在平均上机时间比较差异有统计学意义(t=3.197,P=0.002);两组患儿上机后的并发症比较差异有统计意义(χ2=4.043,P=0.044);两组患儿的治愈率比较差异有统计学意义(χ2=4.320,P=0.038)。结论 HFOV治疗重症MAS安全、有效。
Objective To evaluate the efficiency of conventional mechanical ventilation （ CMV） and high-frequency oscillatory ventilation （ HFOV） in the treatment of neonates meconium aspiration syndrome （ MAS） .Meth-ods Sixty neonates with MAS were randomly divided into CMV group （30 cases） and HFOV group（30 cases）.The parameter of pH , PaO2 , PaCO2 , FiO2 （ inhaled oxygen concentration ） ,OI（ oxygen index ） were monitored before and after mechanical ventilation .Complications and clinical outcomes were compared .Results The pH, PaO2 , PaCO2 , FiO2, OI at 0 h between the two groups were not statistically significant difference （P＆gt;0.05）.At 2 hours, 12 hours, 24 hours,48 hours after ventilation , pH, PaO2 , PaCO2 , FiO2 , OI in the HFOV group improved more quickly than those in the CMV group , with statistically significant difference （ P＆lt;0.05 ） .Mechanical ventilation time in the HFOV group was more shorter than that in the CMV group , with statistically significant difference （t=3.197,P=0.002）. The complications of mechanical ventilation hade statistically significant difference between two groups （χ2 =4.043,P=0.044）.The cure rate had statistically significant difference between two groups （χ2 =4.320,P=0.038）.Conclu-sion HFOV is a safe and effective means for the treatment of severe MAS .
出处
《中国临床新医学》
2014年第5期437-440,共4页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
关键词
新生儿
呼吸衰竭
胎粪吸入综合征
高频振荡通气
常频机械通气
Neonate
Respiratory failure
Meconium aspiration syndrome（MAS）
High-frequency oscillatory ventilation （HFOV）
Conventional mechanical ventilation （CMV）
