摘要
背景:脑卒中后神经网络与运动功能的相关性尚未明确。目的:应用磁共振弥散张量成像研究亚急性期脑梗死后神经网络受损情况,并分析其与神经功能缺陷及运动功能障碍的相关性。方法:将19例亚急性期脑梗死患者和20名正常成人分别进行弥散张量成像检查,分析比较以下参数:各向异性分数、表观扩散系数和各向异性分数指数、表观扩散系数指数。同时对患者进行神经功能缺损和运动功能的各项量表评估,检测10 m步行速度。将脑梗死患者弥散张量成像的各项参数与各项量表及10 m步行速度进行相关性分析。结果与结论:脑梗死患者各向异性分数指数和双侧内囊后肢的各向异性分数值均小于正常对照,且患侧内囊后肢的各向异性分数值小于健侧内囊后肢的各向异性分数值(P<0.05)。患侧内囊后肢的表观扩散系数值、表观扩散系数指数大于正常对照内囊后肢的表观扩散系数值和表观扩散系数指数(P<0.05)。患侧内囊后肢的表观扩散系数值、表观扩散系数指数与下肢Fugl-Meyer评分呈负相关(P<0.05)。提示弥散张量成像参数与下肢运动功能障碍密切相关。脑卒中后的局灶性病变造成神经网络缺损,是下肢运动功能障碍的主要原因。
BACKGROUND：The interaction of neural network and motor function in post-stroke brain tissue remains unclear.
OBJECTIVE：To observe neural network impairment fol owing subacute stroke by using diffusion tensor imaging, and to investigate the relationship with neurological defects and motor dysfunction.
METHODS：A total of 19 patients after subactue stroke and 20 healthy adults were examined with diffusion tensor imaging. The fol owing parameters were compared：fractional anisotropy, apparent diffusion coefficient, asymmetry indices of fractional anisotropy and apparent diffusion coefficient. The neurological defect and motor function were evaluated with the corresponding scales. The 10-meter walking speed was measured. The correlation of diffusion tensor imaging parameters with the scale scores and 10-meter walking speed was analyzed.
RESULTS AND CONCLUSION：The stroke group exhibited reduced fractional anisotropy value asymmetry and fractional anisotropy value in bilateral posterior limbs of the internal capsule. Apparent diffusion coefficient value asymmetry and apparent diffusion coefficient value in the posterior limb of the internal capsule were lower than control unaffected side （P〈0.05）. Apparent diffusion coefficient value and apparent diffusion coefficient value asymmetry in posterior limb of the internal capsule showed a strong negative correlation with Fugl-Meyer assessment scores of the lower extremities （P〈0.05）. Diffusion tensor imaging parameters is closely linked with motor dysfunction of the lower extremities in subacute stroke patients. Local stroke lesion-caused neurological defect is the leading cause of motor dysfunction of the lower extremities.
出处
《中国组织工程研究》
CAS
CSCD
2014年第15期2421-2426,共6页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金(30973165)~~
