摘要
免疫系统防止病原体进入人体及体内传播,免疫系统受损可以引起肠道炎症反应,导致包括炎症性肠病(inflammatory bowel diseases,IBD)在内的慢性疾病.溃疡性结肠炎(ulcerative colitis,UC)是一种患病率增加且病因不明的炎症性肠病,UC患者肠黏膜中IL-33/ST2轴失衡.本文就IL-33/ST2系统在肠道免疫中的作用及在IBD特别是UC中的重要性进行综述.
The immune system prevents pathogens from entering and spreading in the body. Dysfunction of the immune system can activate an intestinal inflammatory response, leading to chronic diseases including inflammatory bowel diseases 0BD）. Ulcerative colitis （UC） is a form of IBD of unknown etiology with increasing prevalence. There is an imbalance in the interleukin-33/homolog of sulfotransferase 2 （IL-33/ST2） axis in UC intestinal mucosa. This paper reviews the role of the IL-33/ST2 system in immunity of the intestinal mucosa and its importance in IBD, especially UC.
出处
《世界华人消化杂志》
CAS
北大核心
2014年第12期1663-1668,共6页
World Chinese Journal of Digestology
