摘要
目的评价粉尘螨滴剂舌下含服免疫治疗特应性皮炎的疗效及安全性。方法采用自身治疗前、后对照比较47例尘螨变应原阳性特应性皮炎患者在接受1年的粉尘螨滴剂舌下含服免疫治疗前、后湿疹面积及严重程度指数(EASI)、皮损受累面积百分比(BSA%)和瘙痒评分及用药评分,并观察复发情况等。结果 43例患者坚持完成1年的疗程,4例退出。治疗后患者湿疹面积及严重程度指数(EASI)、皮损受累面积百分比(BSA%)、瘙痒评分及用药评分分别为(5.83±0.94,10.33%±0.16,2.02±0.48,1.67±0.94)均较其治疗前(32.67±1.92,34.07%±0.21%,8.38±0.45,24.75±8.66)明显减少(P均<0.01)。3例治疗第1周时出现口唇或舌下肿胀、口腔发麻、口痒或干燥;1例局部维持期出现荨麻疹。随访1年时复发率9.30%。结论粉尘螨滴剂舌下含服是治疗尘螨引起的特应性皮炎的一种有效方法,安全性较好。
Objective To evaluate the efficacy and safety of suhlingual immunotherapy with dermatophagoides farinae drops for the treatment of atopic dermatitis. Methods Forty-seven patients with atopic dermatitis, whose allergen tests were positive for dust mites, were enrolled in this self-contrast study. Clinical efficacy was evaluated by EASI （eczema area and severity index） , BSA% （the percentage of body surface area） , pruritus scores and pharmacological score after 1 year of sublingual immunotherapy with dermatophagoides farinae drops and compared with pre-treatment. The recurrent rates were observed for during the follow-up. Results Forty-three patients had completed the one -year treatment and 4 cases were out of the treatment. In comparison with pre - treatment, all parameters were significantly reduced after treatment（5.83 ± 0.94 vs 32.67 ± 1.92 for EASI,10. 33% ±0.16 vs. 34.07% ±0.21% for BSA%, 2.02±0.48 vs. 8.38±0.45 for pruritus scores, 1.67 ± 0.94 vs. 24.75± 8.66 for pharmacological scores, P 〈 0.01 ）. During the first week of treatment, 3 cases experienced oral or sublingual swelling and mouth numbues , itching or dryness. 1 case had localized urticarial during the maintenance phase. The recurrent rates were 0.93% during 1-year follow- up. Conclusion Sublingual immunotherapy with dermatophagoides farinae drops is effective and safe for patients with atopic dermatitis-induced by dust mites.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2014年第6期658-660,共3页
The Chinese Journal of Dermatovenereology
关键词
皮炎
特应性
粉尘螨
免疫治疗
临床观察
Dermatitis
atopic
Dermatophagoides farinae
Immunotherapy
Clinic Study
