期刊文献+

利妥昔单抗联合ATG治疗伴有自身抗体的重型再生障碍性贫血3例

Rituximab and Rntithymocyte Globulin (ATG) for the Treatment of 3 Cases with Severe Aplastic Anemia(SAA) Accompanied with Autoantibodies
原文传递
导出
摘要 [目的]观察利妥昔单抗(rituximab,美罗华)联合ATG(antithymocyte globulin)治疗重型再生障碍性贫血(重型再障,SAA)的疗效,探索部分再障患者的免疫学发病机制。[方法]对收集的3例病例临床资料进行分析。[结果]3例患者经美罗华联合ATG治疗后,2例痊愈,1例血象部分缓解。[结论]部分再障的免疫学发病机制,不但有T淋巴细胞的参与,还有B淋巴细胞介导的体液免疫的参与。
出处 《肿瘤学杂志》 CAS 2014年第5期434-436,共3页 Journal of Chinese Oncology
基金 2012年国家中医临床研究基地业务建设科研专项(ZDZX2012173)
  • 相关文献

参考文献13

  • 1Hirano N,Butler MO,von Bergwelt-Baildon MS,et al.Au-toantibodies frequently detected in patients with aplastic anemia[J].Blood,2003,102(13):4567-4575.
  • 2Hirano N,Butler MO,Guinan EC,et al.Presence of anti-kinectin and anti-PMS1 antibodies in Japanese aplastic anaemia patients[J].Br J I-Iaematol,2005,128:221-223.
  • 3Feng X,Chuhjo T,Sugimori C,et al.Diazepam-binding in-hibitor-related protein 1:a candidate autoantigen in ac-quired aplastic anenna patients harboring a minor popula-tion of paroxysmal nocturnal hemoglobinuria-type cells[J].Blood,2004,104(8):2425-2431.
  • 4Takamatsu H,Feng XM,Chuhjo T,et al.Specific antibod-ies to moesin,a membrane-cytoskeleton linker protein are frequently detected in patients with acquired aplastic ane-mia[J].Blood,2007,109(6):2514-2520.
  • 5Qi Z,Takamatsu H,Espinoza JL,et al.Autoantibodies spe-cific to hnRNP K:a new diagnostic marker for immune pathophysiology in aplastic anemia [J].Ann Hematol,2010,89(12):1255-1263.
  • 6邵宗鸿.再生障碍性贫血的研究[J].基础医学与临床,2007,27(3):233-237. 被引量:43
  • 7涂梅峰,邵宗鸿,刘鸿,何广胜,白洁,施均,曹燕然,王化泉,邢莉民,崔振珠,孙娟,陈辉树,薛艳萍,杨崇礼.肝炎相关再生障碍性贫血的临床特征[J].中华血液学杂志,2005,26(4):239-242. 被引量:28
  • 8陈芾珩,苏永忠,刘元生,庄春兰.病毒性肝炎相关性再生障碍性贫血1例[J].汕头大学医学院学报,2008,21(2):109-110. 被引量:1
  • 9Hansen PB,Lauritzen AM.Aplastic anemia successfully treated with rituximab[J].Am J Hematol,2005,80(4):292-294.
  • 10Gomez-Almaguer D,Jaime-Perez JC,Guillermo J,et al.Antibodies in the treatment of aplastic anemia [J].Arch Immunol Ther Exp,2012,60(2):99-106.

二级参考文献59

共引文献69

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部