摘要
目的探讨声触诊组织量化技术在糖尿病肾病早期诊断中的价值。方法选取63例确诊为2型糖尿病的患者,在血糖控制理想、肌酐正常的前提下根据24h尿微量白蛋白排出量(UA)将患者分为3组,Ⅰ组(UA<30mg)、Ⅱ组(30mg≤UA<300mg)、Ⅲ组(UA≥300mg),同时选取25例健康者为正常对照组(Ⅳ组)。采用声触诊组织量化技术分别测量各分组肾中部实质的剪切波速度(SWV),进行统计学分析。结果各组肾实质SWV值与UA值呈正相关。Ⅰ组、Ⅱ组、Ⅲ组、Ⅳ组的SWV平均值分别为(2.04±0.10)m/s、(2.34±0.16)m/s、(2.76±0.32)m/s、(1.96±0.21)m/s,Ⅰ组与对照组SWV值比较无统计学差异(P>0.05),Ⅱ组、Ⅲ组与对照组SWV值比较均有统计学差异(P<0.05)。Ⅰ组与Ⅱ组、Ⅰ组与Ⅲ组、Ⅱ组与Ⅲ组SWV值比较均有统计学差异(P<0.05)。结论肾实质SWV随肾脏损害的加重而加快,声触诊组织量化技术可以无创地量化反映早期糖尿病肾病患者肾脏损害的程度,辅助诊断。
Objective To evaluate the value of acoustic radiation force impulse （ ARFI ） to diabetic nephropathies. Methods Sixty-three cases with type 2 diabetes were classified into three groups according to urinary albumin excretion rate （UA） ： group Ⅰ （ UA 〈 30 mg）, group Ⅱ （30 mg ≤ UA 〈 300 mg）, groupⅢ （ UA ≥ 300 mg）. Twenty normal persons were selected as controls （group Ⅳ ）. In each group, SWV were measured to analyze the renal parenchymal elasticity in different stages. Results The numerical value of SWV was positively correlated with that of UA. The mean value of stageⅠ , Ⅱ, Ⅲ, Ⅳ were （2.04 ± 0. 10 ） m/s, （2. 34 ± 0. 16） m/s, （2. 76 ± 0. 32） m/s, （ 1.96 ± 0. 21 ） m/s. There was no significant difference in shear wave velocity between stage I and controls （ P 〉 0.05 ）, and there was significant difference in shear wave velocity between stage Ⅰ and stage Ⅱ , stage Ⅰ and stageⅢ, stage Ⅱ and stage Ⅲ （P 〈 0. 05）. Conclusions The more severe the renal dysfunction, the more obvious the increase of SWV. ARFI is valuable in early diagnosis and evaluation of diabetic nephropathy by measuring SWV.
出处
《中华临床医师杂志（电子版）》
CAS
2013年第4期129-131,共3页
Chinese Journal of Clinicians(Electronic Edition)
基金
山东省教育厅课题(J12LL08)
关键词
糖尿病肾病
超声检查
声触诊组织量化技术
Diabetic nephropathies
Uhrasonography
Acoustic radiation force impulse
