摘要
目的:比较VKC患儿与正常儿童泪液中细胞因子白细胞介素-4(IL-4),白细胞介素-5(IL-5)和白细胞介素-13(IL-13)的表达量的变化,以及分析两组之间有无统计学差异。方法:收集10例春季角结膜炎(VKC)患儿与16例正常受试者(CT)的泪液;采用液体芯片技术测量两组泪液中IL-4,IL-5,IL-13的浓度,使用U检验来比较两组之间的差异有无统计学意义。结果:VKC组泪液中IL-4的浓度为1.09±0.73 pg/mL,IL-5的浓度为1.68±1.43 pg/mL,IL-13的浓度为1.90±1.59 pg/mL;与正常受试者(CT)相比,明显升高,两组之间比较差异均有统计学意义(P<0.05)。结论:分析VKC患儿泪液中的细胞因子在了解VKC的发病机制中可能可以起到重要的作用,以及可以提供新的治疗方向。
Objective： To compare the concentrations of IL-4, IL-5 and IL-13 in tear samples from active VKC patients and normal subjects（CT）. Methods： Tear samples were collected from 16 normal subjects and 10 active VKC patients. Cytokine concentrations were measured by Bio-Plex ProTM magnetic color-bead-based multiplex assay. Mann Whitney U test was used to compare the differences between two groups. Results： The concentrations of IL-4, IL-5, IL-13 were significantly increased in active VKC patients compared with normal subjects（CT）. Conclusions： The tear concentrations of the three cytokines from the VKC group were significantly higher,which may indicate VKC is related to the increase of cytokines and may provide new treatments.
出处
《现代生物医学进展》
CAS
2014年第14期2683-2685,共3页
Progress in Modern Biomedicine
关键词
春季角结膜炎
细胞因子
泪液
Vernal keratoconjunctivitis（VKC）
Cytokines
Tears
