摘要
目的：探讨复方乳酸依沙吖啶散中乳酸依沙吖啶含量的测定方法。方法排除影响乳酸依沙吖啶吸光度值的因素，筛选出供试液制备的最佳方法：减少取样量，采用微孔滤膜于80℃以下条件下加压过滤。采用紫外分光光度法在362 nm处测定吸光度（A），计算乳酸依沙吖啶含量。结果乳酸依沙吖啶在5~22.5 mg/L（r=0.9997）范围内线性关系良好，高、中、低含量样品（n=5）平均测定率分别为93.132%、93.074%和93.261%。结论该方法简单、快速，测定结果符合要求，可作为复方乳酸依沙吖啶散中乳酸依沙吖啶含量的测定方法。
Objective To discuss the content determination of Ethacridine Lactate in Compound Ethacridine Lactate Powder. Methods The best preparation method of reducing the amount of sample and pressuring filter with mi-cropore film below 80℃ was screened by excluding the interference factors. The absorbance （ A） and content were detec-ted at 362 nm with UV spectrophotometry. Results The Ethacridine Lactate had good linear relationship during 5 -22. 5 mg/L （r=0. 9997） of linear range. The average detection rates of samples with high, middle and low contents （n=5） were 93. 132%, 93. 074% and 93. 261% respectively. Conclusion The method is simple, quick and feasi-ble, and can be used to detect the content of Ethacridine lactate in Compound Ethacridine Lactate Powder.
出处
《解放军医药杂志》
CAS
2014年第5期82-85,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
关键词
质量控制
乳酸依沙吖啶
复方乳酸依沙吖啶散
分光光度法
紫外线
Quality control
Ethacridine Lactate
Compound ethacridine lactate powder
Spectrophotometry,ultraviolet
