摘要
目的:优化氯波必利生物黏附缓释片的处方和制备工艺。方法:以累积释放度为指标,采用正交设计方法,对制剂辅料羟丙基甲基纤维素(HPMC)、卡波姆、淀粉及乳糖的用量进行考察,确定氯波必利生物黏附缓释片处方。结果:缓释片规格为每片0.1 g,以HPMC和卡波姆为生物黏附和骨架材料,乳糖为稀释剂,淀粉为填充剂和崩解剂,每100片用量分别为5.5、2.2、1.2、2.0g。与氯波必利普通片比较,缓释片具有显著缓释和黏附性能。结论:本制剂制备工艺简单,符合缓释、黏附要求。
OBJECTIVE：To optimize the formulation and preparation processes of Clebopride bioadhesive sustained-release tablets.METHODS：Accumulative release rate as index,orthogonal design was adopted to optimize the amount of HPMC,carbomer,starch and glucose to determine the formulation of Clebopride bioadhesive sustained-release tablets.RESULTS：The optimal formulation was as follows：HPMC and carbomer as bioadhesive and skeletal material,lactose as diluent,starch as a filler and a disintegrant,0.1 g each sustained-release tablet.The amounts of above parameters in 100 tablets were 5.5,2.2,1.2 and 2.0 g,respectively.Compared with common tablets,Clebopride sustained-release tablets showed the proporties of sustained release and adhesion.CONCLUSIONS：The technology is simple and meets clinical needs of sustained release and adhesion.
出处
《中国药房》
CAS
CSCD
2014年第21期1964-1966,共3页
China Pharmacy
基金
湖南省科技厅科技计划项目(No.2012SK3104)
关键词
氯波必利
生物黏附缓释片
处方筛选
累积释放度
Clebopride
Bioadhesive sustained-release tablets
Formulation screening
Accumulative release rate
