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依立替康联合顺铂经支气管动脉灌注化疗治疗小细胞肺癌临床观察 被引量:2

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摘要 目的:观察伊立替康联合顺铂方案经支气管动脉灌注化疗治疗小细胞肺癌的近期疗效及安全性。方法43例小细胞肺癌肺癌患者采用依立替康100~160 mg/m2,分第1天、第8天2次给药,第1天采用 Seldinger 氏法,经皮股动脉穿刺插管。行选择性支气管动脉造影,确认肿瘤供血动脉后插管灌注化疗药物,第8天静脉滴注,顺铂100 mg/m2第1天支气管动脉灌注,第2、3天静脉滴注。21 d 为1周期。观察评价近期疗效、毒副反应和生存期。结果43例患者 CR +PR 29例(67.4%),SD 7例(16.3%),PD7例(16.3%)。中位生存期为13.2个月,1年生存率46.5%,2年生存率23.3%。未见严重不良反应。结论依立替康联合顺铂经支气管动脉灌注化疗治疗小细胞肺癌疗效较好,是一种治疗小细胞肺癌安全有效的方案。
出处 《河北医药》 CAS 2014年第9期1370-1372,共3页 Hebei Medical Journal
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参考文献12

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