摘要
目的:观察康复新液对实验性大鼠皮肤切割伤痂下愈合的影响。方法:建立大鼠皮肤切割伤伤口痂下愈合模型,以不同浓度的康复新液(高剂量组、低剂量组)作用于伤口,观测创面愈合情况,计算愈合百分率,并分别于术后第4、7、14天取创面组织,HE常规染色观察创面新生肉芽组织及形态学改变。结果:各时间点康复新液高、低剂量组创面平均愈合率均显著高于阴性对照组,差异有统计学意义(P<0.01)。HE染色显示,与阴性对照组相比,术后第4、7天,康复新液各组肉芽组织丰富而炎性细胞浸润较少,术后第14天,康复新液组胶原纤维数量更多,排列更整齐,表皮结构更加完整。结论:康复新液对促进大鼠皮肤切割伤的痂下愈合作用显著。
Objective： To investigate the effect of Kangfuxin liquid on the rat skin during the process of subcrustal healing. Methods： Excision wounds of skin were produced in experimental rats which were divided into Kangfuxin liquid high-dose group and low-dose group. Observation of wound healing, calculation of the healing rate, and histological examination were undertaken at different time points. Results： The average healing rate of both high-dose and low-dose group were significantly higher than those of negative group （P〈0.01）. HE staining showed that compared with negative group, less inflammatory cells infiltration but more new granulation tissue were found in Kangfuxin liquid groups than those in negative group after 4 and 7 days of wounding, and epidermis hyperplasia. Conclusion： Kangfuxin liquid can significantly promote subeschar wound healing ability of rats.
出处
《天津医科大学学报》
2014年第3期192-195,共4页
Journal of Tianjin Medical University
关键词
康复新液
皮肤切割伤
组织病理学
大鼠
Kangfuxin liquid
cutaneous excision wound
histopathology
rats
