摘要
目的探讨合并代谢综合征(MS)的不稳定型心绞痛(UA)患者冠状动脉斑块的血管内超声影像学特征。方法回顾性分析106例UA患者,其中合并MS组51例,非MS组55例。比较两组体质指数(BMI)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、餐后2h血糖(2hPBG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)和甘油三酯(TG)等水平。测定两组患者病变血管的外弹力膜面积、管腔面积、斑块面积、斑块负荷、重构指数及斑块成分等指标。结果 MS组BMI、SBP、DBP、FPG、2hPBG、TG高于非MS组(P<0.05),HDL低于非MS组(P<0.05)。MS组病变血管的管腔面积、重构指数高于非MS组(P<0.05),MS组斑块成分中坏死核心比例高于非MS组(P<0.05),而钙化斑块比例低于非MS组(P<0.05)。多元线性回归分析显示FPG、SBP、BMI对病变血管的管腔面积有显著性影响(P<0.001)。结论合并MS的UA患者病变血管多合并正性重构,斑块面积较大,斑块坏死成分含量更多,提示斑块易损性增加。
Aim To evaluate the characteristics of coronary artery lesion in unstable angina （UA） patients with metabolic syndrome （MS） by intravascular ultrasound（IVUS）. Methods According to being complicated with MS or not, 106 patients with UA were reviewed and divided into MS group（ n = 51 ） and non-MS group （ n = 55 ）. The levels of body mass index（ BMI）, systolic blood pressure （ SBP）, diastolic blood pressure （ DBP）, fasting plasma glucose （ FPG）, 2h postprandial blood glucose（2hPBG）, total cholesterol （TC）, high density lipoprotein （HDL）, low density lipoprotein （ LDL）, triglyceride （TG） were observed. The external elastic membrane （EEM） cross section area, lumens area, plaque area, plaque burden, remodeling index （RI） of coronary arteries and the plaque composition were measured by IVUS in two groups. Results BMI, SBP, DBP, FPG, 2hPBG and TG in MS group were significantly higher than those in non- MS group （ P 〈 0. 05 ）. HDL was lower than that in non-MS group （ P 〈 0. 05 ）. The plaque area and remolding index in MS group were larger than those in non-MS group （ P 〈 0. 05 ）. Compared with non-MS group, there were more necrotic core and less dense calcium in the atheroma plaque of MS group （ P 〈 0. 05 ）. Multiple regression analysis showed that FPG, SBP and BMI remained as predisposing risk factors for plaque area levels （P 〈 0.001 ）. Conclusions From our observasion we concluded that in unstable angina patients with MS, the remolding index, plaque area and the amount of necrotic core material are greater in the culprit vessel. Therefore, the plaque of culprit vessel is more vulnerable.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2014年第3期257-260,共4页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目(81270281
81200148)
关键词
稳定型心绞痛
代谢综合征
血管内超声
斑块特征
Unstable Angina
Metabolic Syndrome
Intravascular Ultrasound
Plaque Characteristic
