摘要
目的分析血清降钙素原(PCT)在诊断老年患者四肢骨折术后感染的临床意义。方法选择2010年1月—2013年6月采用经皮切开内固定术治疗的四肢骨折95例,依据术后是否并发感染分为感染组45例和非感染组50例,两组均于术后第1、3、5及7天采集静脉血检测炎性指标变化,评估其对术后感染的诊断价值。结果非感染组术后第3、5、7天CRP、IL-6及WBC和术后第7天PCT均低于术后第1天,感染组术后第3、5、7天PCT、CRP、IL-6及术后第3天WBC均高于术后第1天(P<0.05)。术后第3天感染组血PCT与CRP和IL-6均呈显著正相关(r=0.507,r=0.500,P<0.01)。PCT为2.1μg/L时对感染的诊断敏感性和特异性均优于CPR及IL-6。结论 PCT可用于老年四肢骨折术后感染的早期诊断。
Objective To analyze the clinical significance of serum procalcitonin （PCT） in diagnosis of postop- erative infection in elderly patients with extremities fractures. Methods A total of 95 elderly patients with extremities fractures during January 2010 and June 2013, who underwent percataneous incision of internal fixation, were divided into postoperative infection group （n = 45） and non concurrent infection group （n = 50）. Inflammatory indexes were detected on postoperative 3^th , 5^th and 7^th d by collecting the venous blood in the two groups, and the clinical significance of indexes in diagnosis of postoperative infection was evaluated. Results In non concurrent infection group, levels of C-reactive protein （CRP） , interleukin-6 （IL-6） and white blood cell （WBC） on postoperative 3^th , 5^th and 7^th d, and procaleitonin （PCT） on postoperative 7^th d were lower than those on postoperative 1^st d, while levels of PCT, CRP and IL-6 on postop- erative 3^th , 5^th and 7^th d, and WBC on postoperative 7^th d were higher than those on postoperative 1^st d in infection group （P 〈 0.05）. In infection group, levels of PCT, CRP and IL-6 showed significant positive correlations on postoperative 3^th d （ r = 0. 507, r = 0. 500, P 〈 0.01 ）. Diagnostic sensitivity and specificity for infection were better when PCT was 2.1 μg/L than those of CPR and IL-6. Conclusion PCT can be used in early diagnosis of postoperative infection in eld- erly patients with extremities fractures.
出处
《解放军医药杂志》
CAS
2014年第4期80-83,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
关键词
骨折
老年人
术后感染
降钙素
Fracture
Elderly
Postoperative infection
Calcitonin
