摘要
α2-巨球蛋白(α2-Macroglobulin,α2M)是普遍存在于脊椎动物和无脊椎动物血浆中的一种非特异性的大分子蛋白酶抑制剂,本文综述了近年来α2-巨球蛋白分子结构、作用机制、生理功能和进化等方面的研究进展,以期为更深入地了解α2-巨球蛋白的结构与功能的相关性及进化提供参考.
α2-Macroglobulin( α2M) is a kind of non-specific and large proteinase inhibitor which widely presents in plasma of vertebrates and invertebrates. The α2M's molecular structure,mechanism of action and physiological function were summarized and its conservative property on sequence and expression patterns among different species during evolution were discussed also,which can provide the reference on deeply understanding the structure and function of alpha 2-macroglobulin correlation and evolution.
出处
《鲁东大学学报(自然科学版)》
2014年第2期133-137,154,共6页
Journal of Ludong University:Natural Science Edition
关键词
Α2-巨球蛋白
分子结构
作用机制
生理功能
进化
α2-Macroglobulin
molecular structure
mechanism of action
physiological function
evolution