摘要
目的通过对慢性阻塞性肺疾病(COPD)患者应用小剂量茶碱后,肺功能、6min步行试验、CAT评分等指标的检测,探讨小剂量茶碱对COPD患者预后的影响。方法应用随机分组、对照及自身对照的方法 ,将937例COPD患者分为治疗组(常规治疗+茶碱缓释片0.1,2次/d)和对照组(常规治疗),对应用茶碱治疗前后的各项指标进行统计学比较。结果①治疗组的COPD患者经过90d的治疗,治疗后第1秒用力呼气容积实测值与预计值的百分比(FEV1%预计值)及FEV1和用力肺活量实测值与预计值的百分比(FEV1/FVC%)较治疗前明显提高;6MWT提高;CAT评分、mMRC评分下降(P<0.05)。②治疗后治疗组较对照组患者的上述指标均有改善(P<0.05)。结论应用小剂量茶碱可改善COPD患者的肺功能,提高患者的活动能力及生活质量,可能延缓疾病进展。
Objective To observe the effect of low-dose theophylline on the prognosis of patients with COPD through pulmonary function ,the six-minute walking test （6MWT）,CAT scores,mMRC score.Methods Using random allocation ,controlled and self-control methods ,937 COPD patients were divided into treatment group （ conventional thera-py＋oral theophylline 0.4g/day） and control group（conventional therapy）.The applications of theophylline were com-pared between before and after treatment .Results ①Measuring the expiratory volume in one second （FEV1） and forced vital capacity（FVC） through lung function before and after treatment within 90 days,the two indexes were improved sig-nificantly in the treatment group of COPD patients （P〈0.05）.6MWT were improved;CAT scores,mMRC score were re-duced .②After therapy ,compared with control group ,patients in treatment group of the above indexes were improved （ P〉0.05） .Conclusion Low-dose theophylline could improve the lung function of COPD patients ,improve the patient＆#39;s activity ability and the quality of life ,may slow disease progression .
出处
《潍坊医学院学报》
2014年第2期126-128,共3页
Acta Academiae Medicinae Weifang
关键词
茶碱
慢性阻塞性肺疾病
肺功能
活动能力
Theophylline
Chronic obstructive pulmonary disease
Lung function
Activity
