7LUO W,LI Y P,HE Y,et al. Synthesis and evaluation ofheterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents [J]. Eur J Med Chem,2011,46(6):2609-2616.
8PAPPOLLA M A,CHYAN Y J,POEGGELER B,et al.Alzheimer 茁protein mediated oxidative damage ofmitochondrial DNA:prevention by melatonin[J]. J PinealRes,2007,27(4):226-229.
9RODR侏GUEZ-FRANCO M I,FERNANDEZ-BACHILLERM I,PEREZ C,et al. Novel tacrine-melatonin hybrids asdual-acting drugs for Alzheimer disease, with improvedacetylcholinesterase inhibitory and antioxidant properties[J]. J Med Chem,2006,49(2):459-462.
10FERN佗NDEZ BACHILLER M I,P佴REZ C,CAMPILLO NE,et al. Tacrine – melatonin hybrids as multifunctionalagents for Alzheimer ' s disease, with cholinergic,antioxidant,and neuroprotective properties[J]. Chem MedChem,2009,4(5):828-841.
2LABESHIMA T. Trial to produce animal model of Alzheimer "s disease by continuous infusion of beta- amyloid protein to the rat eerebralventricle [ J ]. Nihon Shinkei Seishin Yaknrigaku Zasshi, 1995,15 (5) :411-418.
3SHAH R S, LEE H G, XIONG W Z, et al. Current appro- aches in the treatment of Alzheimer's disease [ J ]. Biomed Pharmacother, 2008,62 (4) : 199-207.
4BUTFERFIELD D A, REED T, NEWMAN S F. Roles of amyloid beta-peptide-ass-ciated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer "s disease and mild cognitive impairment[ J]. Free Radic Biol Med ,2007,43 ( 5 ) :658-677.
5DAVIS L, STONEHOUSE W, LOOTS D T, et al. The effects of high walnut and cashew nut diets on the antioxidant status of subjects with metabolic syndrome [ J ]. Eur J Nutr, 2007, 46(3) :155-164.
6HALVORSEN B L, HOLTE K, MYHRSTAD M C W, et al. A systematic screening of total antioxidants in dietary plants [J]. J Nutr,2002,132(3) :461-471.
7ESTRUCH R, ROSS E. Effects of a traditional mediterranean diet on lipoprotein oxidation [ J ]. Arch Int Med, 2007,167 (11) :1195-1203.