摘要
MicroRNA（miRNA）是一类长20～25个核苷酸序列、非编码的内源性单链RNA分子,通过与靶mRNA 3’ UTR结合方式,参与转录后调控.miRNA在肿瘤中的作用研究也成为近年的研究热点.越来越多的证据表明miRNA参与胶质瘤细胞增殖、凋亡、侵袭、转移、细胞耐药性及新生血管形成等病理生理过程.miRNA可能为胶质瘤治疗提供新的途径.文中对近年来miRNA在胶质瘤中的研究进行综述.
MicroRNAs is a kind of approximately 20 to 25 nucleotide sequence ot ttle enoogenous non- coding single-stranded RNA molecules, by binding to the target mRNA 3 ＇UTR, involved in the post- transcription regulation. The research about the role of microRNAs in cancer has also become a hotspot in recent years. A growing evidences suggested that microRNAs involved in the glioma cell pathophysiological process, such as proliferation, apoptosis, invasion, metastasis, cell resistance and the formation of new blood vessels. MicroRNAs may provide a new approach for the treatment of gliomas. Recent advances of microRNA research in gliomas were reviewed.
出处
《中国临床神经科学》
2014年第2期203-207,218,共6页
Chinese Journal of Clinical Neurosciences
基金
上海市自然科学基金项目(编号:11ZR1405100)
