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中央杏仁核对大鼠心脏伤害性感受的调节作用 被引量：1

The modulation of central amygdale on cardiac nocicepption in rats
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摘要 目的观察电刺激大鼠中央杏仁核(CeA)对心脏伤害性感受的调节作用。方法选择成年雄性SD大鼠,以心包内注射辣椒素(CAP)诱发的大鼠背斜方肌肌电为指标,制备心脏痛动物模型;对照组分为正常对照组和心包内注射生理盐水对照组。利用免疫组织化学方法观察心脏痛模型大鼠CeA内c-fos表达的变化;并利用电生理学方法观察电刺激CeA(强度分别为30μA和70μA)对心包内注射CAP引起的肌电(EMG)反应的影响。结果①与正常对照组相比,心包内注射辣椒素组CeA内c-fos表达量显著升高且有统计学意义;正常对照组和心包内生理盐水对照组CeA内c-fos表达量则无统计学差异;②30μA电刺激CeA后,大鼠背斜方肌的EMG较对照组明显减弱,总放电率为对照组的(78.58±4.62)%(P<0.05);70μA电刺激后总放电率为对照组的(54.89±3.98)%(P<0.05)。结论大鼠中央杏仁核可能参与了大鼠心脏伤害性感受信息的传入,且具有下行抑制性调节作用。 Objective To study the modulation of central amygdale （CeA） on cardiac nociception with electrical stimulation in rats. Methods The heart pain model of adult male Sprague-Dawley rats was established with intrapericardial injection of capsaicin; then the evoked electromyography （EMG） responses in the spinotrapezius （SPT） were observed as an index. Immunohistochemical method was used to observe the expression of c-los in CeA; The rats were divided into normal control group, intrapericardial saline injection control group, and intrapericardial capsaicin injection group. The changes of EMG responses after electrical stimulation on CeA （intensity of 30 μA and 70 μA） were observed separately by electrophysiology in different groups. Results ① Compared with normal control group, intrapericardial capsaicin injection group had significantly increased expression of c-fos in CeA. However, c-fos expression did not differ significantly between intrapericardial saline injection group and normal control group; ② After 30μA electrical stimulation on CeA, EMG response in SPT significantly decreased in intrapericardial capsaicin injection group compared with that in control group; the total discharge rate was （78. 584±4.62） % of that of control group （P〈0.05）. After 70 μA electrical stimulation on CeA, the total discharge rate was （54.89± 3. 98）% of that of control group （P 〈0.05）. Oonclusion CeA may be involved in cardiac nociceptive transmission in rats and has inhibitorv effects on the modulation of rat cardiac nociception
作者 雷冬玉 李静 孙娜 李婧 王锐安 魏媛媛 杨小立 杜剑青
机构地区 新疆医科大学基础医学院生理学教研室 西安医学院基础医学部生理学教研室 西安交通大学医学院生理学与病理生理学系 西安交通大学医学院第一附属医院疼痛科
出处 《西安交通大学学报（医学版）》 CAS CSCD 北大核心 2014年第3期320-323,共4页 Journal of Xi’an Jiaotong University（Medical Sciences）
基金 国家自然科学基金资助项目(No.31171068)~~
关键词 中央杏仁核 免疫组织化学 电刺激 心脏伤害性感受 central amygdala immunohistochemistry electrical stimulation cardiac nociception
分类号 R338 [医药卫生—人体生理学]
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参考文献17

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二级参考文献33

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共引文献9

同被引文献23

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西安交通大学学报（医学版）
2014年 第3期

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