4Huang X J, Wiernik PH, Klein RS, et al. Arsenic trioxide induces apoptosis of myeloid leukemia cells by activation of caspases[J]. Med Oncol, 1999, 16(1 ) : 58-64.
5Wang ZG, Rivi R, Delva L, et al. Arsenic trioxide and melarsoprol induce prograrnmed cell death in myeloid leukemia cell lines and function in a PML and PML-RARalpha independent manner [J]. Blood, 1998, 92(5): 1497-1504.
6Perkins C, Kim CN, Fang G, et al. Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr- Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x (L) [J]. Blood, 2000, 95(3) : 1014-1022.
7Ramos AM, Fern6nde ZC, Amr6n D, et al. Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells [J]. Blood, 2005, 105(10) : 4013-4020.
8Lemarie A, Morzadec C, Mrino D, et al. Arsenic tr/oxide induces apoptosis of human monocytes during macrophagic differentiation through nuclearfactor-kappaB-related survival pathway down regulation [J]. J Pharmacol Exp Ther, 2006, 316 (1): 304-314.
9Goussetis DJ, Ahman JK, Glaser H, et al. Autophagy is acritical mechanism for the induction of the antileukemic effects of arsenic trioxide [J]. J Biol Chem, 2010, 285 (39): 29989-29997.
10Goussetis DJ, Gounaris E, Wu EJ, et al. Autophagic degradation of the Bcr-Abl oncoprotein and generation of antileukemic responses by arsenictrioxide [J]. Blood, 2012, 120 (17): 3555-3562.