摘要
目的 探讨血清降钙素原（PCT）和超敏C反应蛋白（hsCRP）用于感染性疾病早期诊断的价值.方法 随机采集79例感染性疾病患者血清,其中细菌性感染54例,非细菌性感染25例,采用免疫荧光法测PCT;采用免疫比浊法测hsCRP.结果 细菌性感染患者PCT阳性率显著高于非细菌感染患者（x2=48.337,P＜0.01）,敏感性92.5％,特异性88.0％;细菌性感染患者hsCRP阳性率显著高于非细菌感染患者（x2=22.347,P＜0.01）,敏感性88.9％,特异性56.0％,阳性预测值（88.9％）与阴性预测值（70.0％）均低于PCT（阳性预测值94.3％和阴性预测值84.6％）.结论 PCT在细菌性感染患者血清中明显升高,具有较高的敏感性和特异性,可作为临床新的炎症标志物,有助于病情的早期评估、预后评价及疗效观察.
Objective To explore the clinical applications of the PCT and hs-CRP in inflammatory diseases.Methods The sera of 79 infectious patients were randomly collected.54 samples were bacterial infectious patients,25 samples were nonbacterial infectious patients.The serum levels of PCT and hsCRP in 79 infectious cases were detected by immune fluorescence and Immunoturbidimetry respectively.Results The positive rate of PCT in bacterial infectious patients were much higher than that in nonbacterial infectious patients （x2 =48.337,P 〈 0.01）,and the sensitivity was 92.5%,the specificity was 88.0% ;The positive rate of hs-CRP in bacterial infectious patients were much higher than that in nonbacterial infectious patients （x2 =22.347,P 〈 0.01）,and the specificity was 88.9%,the specificity was 56.0%.The positive predictive value （88.9%） and negative predictive value （70.0%） of hs-CRP were lower than those of PCT （positive predictive values of 94.3% and negative predictive value of 84.6%）.Conclusion Theserum levels of PCT in inflammatory diseases were significantly increased with an high sensitivity and high specificity.Thus,it may be used as a new marker of inflammatory,which can be helpful in the early evaluation of infectious disease and the observation of curative efficacy.
出处
《中国基层医药》
CAS
2014年第8期1185-1186,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
感染性疾病
降钙素原
C反应蛋白质
Inflammatory disease
Serum procalcitonin
C-reactive protein
