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IL-12、IL-18与复发性流产的相关性研究

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摘要 目的通过检测复发性流产患者血清中IL-12与IL-18水平,探讨其与复发性流产的关系。方法选取复发性流产孕妇(RSA组)、健康早孕妇女(HEP组)和健康未孕妇女(HNP组)各50例,采用ELISA法测定血清中IL-12与IL-18浓度。结果测定RSA组患者血清中IL-12与IL-18的水平显著高于HEP组及HNP组,且差异具有统计学意义(P<0.05),HEP组血清中IL-12与IL-18水平高于HNP组,但无统计学意义(P>0.05)。血清IL-12质量浓度在46.33pg/mL时预测复发性流产的灵敏度为86%、特异度为70.3%;IL-18质量浓度在51.78pg/mL时灵敏度为98%、特异度为65.2%。结论复发性流产患者血清IL-12与IL-18的水平较正常妊娠妇女显著增高,IL-12≥46.33pg/mL、IL-18≥51.78pg/mL作为复发性流产的一种临床诊断指标,具有较高的灵敏度和特异度,提示IL-12与IL-18与复发性流产的发生具有相关性,且有望成为新的判定流产发生几率的参考指标。
作者 董晖 吴振兰 王丽 赵建强
机构地区 山东省潍坊医学院研究生院处 山东省潍坊市人民医院
出处 《中国优生与遗传杂志》 2014年第3期81-82,85,共3页 Chinese Journal of Birth Health & Heredity
关键词 复发性流产 IL-12 IL-18 妊娠
分类号 R714.21 [医药卫生—妇产科学]
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参考文献9

  • 1Wegmann TG, Lin H, Guilbert L, Mossman TR. Bidirectional cytokine interactions in maternal foetal relationships:is successful pregnancy a Th2 phenomenon[ J ]. Immunol Today, 1993,14:353 - 356.
  • 2Tayade C, Hilchie D, He H,et al. Genetic deletion of placenta growth factor in mice alters uterine NK cells[J]. J Immunol,2007,178 (7) : 4267 - 75.
  • 3Makhseed M, Raghupathy R, Azizich F,et al. Mitogeninduced cyto- kine responses of maternal peripheral blood lymphocytes indicate a differential Thl - type bias I normal pregnancy and pregnancy failure [ J]. Am J Reprod Immunol, 1999,42: 273 - 281.
  • 4Makhseed M, Raghupathy R, Azizich F, et al. Thl and Th2 cytokine profiles in recurrent aborters with successful pregnancies and with subsequent abortions[J]. Hum Repmd,2001,16: 2219 -2226.
  • 5Lira KJL,Li TC,Weetman AP,Coeke ID,Odukoya OA,Ajjan RA,et al. The role of T helper cytokines in human reproduction [ J ]. Fertil Steri1,2000,73: 136 - 142.
  • 6Rhoda Wilson, Carol Jenkins, Helen Miller, et al. Abnormal cytokine levels in non - pregnant women with a history of recurrent miscarriage [ J ]. European Journal of Obstetrics&Gynecology and Reproductive Biology,2004,115 ( 1 ) : 51 - 54.
  • 7Readdy P. Interleukin -18 :recent advance [ J ]. Curr Opin Hematol, 2004,11 (6):405-10.
  • 8王虹,张学勤.白细胞介素18在妊娠中的作用及相关病理妊娠[J].医学综述,2010,16(10):1453-1456. 被引量：5
  • 9Wilson R, Moor J, Jenkins C, et al. Abnormal first trimester serum in- terleukin 18 levels are associated with a poor outcome in women with a history of recurrent miscarriage [ J]. Am J Reprod Immuno1,2004, 51 ( 2):156-159.

二级参考文献23

  • 1Xu D,Trajkovic V,Hunter D,et al.IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic background[J].Eur J Immunol,2000,30(11):3147-3156.
  • 2Liu B,Mori I,Hossain MJ,et al.Interleukin-18 improves the early defence system against influenza virus infection by augmenting natural killer cell-mediated cytotoxicity[J].J Gen Virol,2004,85 (2):423-428.
  • 3Huang H Y,Chan SH,Yu HT,et al.Interleukin-18 system messenger RNA and protein expression in human endometrium during the menstrual cycle[J].Fertil Steril,2006,86(4):905-913.
  • 4Murakami Y,Otsuki M,Kusumoto K,et al.Estrogen inhibits interleukin-18 mRNA expression in the mouse uterus[J].J Reprod Dev,2005,51(5):639-647.
  • 5Chaouat G,Zourbas S,Ostojic S,et al.A brief review of recent data on some cytokine expressions at the matemo foetal interface which mightchallenge the classical TM/Th2 dichotomy[J].J Reprod Immunol,2002,53(1/2):241-256.
  • 6Guilbert LJ.There is a bias against type 1 (inflammatory) cytokine expression and function in pemgnaey[J].J Reprod Immunol,1996,32(2):105-110.
  • 7Okamura H,Tsutsui H,Kashiwamura S,et al.Interleukin-18:a novel cytokine that augments both innate and acquired immunity[J].Adv Immunol,1998,70(3):281-312.
  • 8Okamura H,Kashiwamura S,Tsutsui H,et al.Regulation of interferon-gamma production by IL-12 and IL-18[J].Curr Opin Immunol,1998,10(3):259-264.
  • 9Yoshimoto T,Takeda K,Tanaka T,et al.IL-12 up-regulates IL-18 receptor expression on T cells,Thl cells,and B cells:synergism with IL-18 for IFN-gamma production[J].J Immunol,1998,161 (7):3400-3407.
  • 10Xu D,Chan WL,Leung BP,et al.Selective expression and functions of interleukin 18 receptor on T helper(Th) type 1 but not Th2 cells[J].J Exp Med,1998,188(8):1485-1492.

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中国优生与遗传杂志
2014年 第3期

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