摘要
目的探讨孕早期中期胎儿颈项透明层厚度(NT)与羊水染色体核型分析的相关性。方法回顾性分析450例孕中期羊水染色体核型分析的孕妇,研究其胎儿NT值与染色体核型及妊娠结果的关系。结果 450例病例检出异常核型20例,检出率4.44%;其中NT≤2.5 mm 342例,检出异常核型2例,检出率0.59%。胎儿NT≥2.5 mm 108例,异常核型18例,占16.7%,其中74例3.5 mm≥NT≥2.5mm的胎儿检出染色体异常5例,检出率为6.7%;34例NT≥3.5 mm的胎儿检出染色体异常13例,检出率为38.2%,两组异常核型检出率的差异有统计学意义(P<0.05)。结论胎儿NT增厚是孕早期中期筛查胎儿染色体异常的敏感而有效的超声指标,羊水染色体核型分析作为胎儿NT≥3.5 mm孕妇重要的产前诊断方法。
Objective： To investigate the first and second stage of sternuchal translucency correlation analysis（ NT） and karyotype of amniotic fluid. Methods： Relative analysis of the pregnant women who was in amniotic karyotype analysis in 450 cases. Consider the NT value and the relationship between karyotype and pregnancy outcome. Results： Among 450 cases,20 cases with abnormal karyotypes,the detection rate 4. 44%; the NT ≤ 2. 5 mm. Among 342 cases,2 cases were found with abnormal karyotypes,and the detection rate is 0. 59%. 108 cases Fetal NT ≥ 2. 5 mm,18 cases abnormal karyotype,accounted for 16. 7%,including 74 cases of 3. 5 mm ≥ NT ≥ 2 5mm,they were detected fetal chromosomal abnormalities in 5 cases,the detection rate was 6. 7%; 34 patients with NT ≥ 3. 5 mm,the babies were detected in 13 cases with fetal chromosomal abnormalities,and the detection rate was 38. 2%. There is statistical significance between the differences of two groups of abnormal karyotype（ P 0. 05）. Conclusion： Fetal NT thickening ultrasound- index is sensitive and effective in first and second trimester screening for fetal chromosomal abnormalities. Chromosomal karyotypes of amniotic fluid are very important for pregnant women（ l NT ≥ 3. 5 mm） as the method for prenatal diagnosis of fetal.
出处
《中国优生与遗传杂志》
2014年第3期48-49,共2页
Chinese Journal of Birth Health & Heredity
关键词
胎儿颈项透明层厚度
羊水
染色体核型分析
Fetal nuchal translucency thickness
Amniotic fluid
Karyotype analysis
