摘要
目的观察腹腔镜卵巢打孔术联合自拟养精种子汤以及来曲唑促排卵两种方案治疗难治性多囊卵巢综合征(PC0S)不孕患者的临床疗效。方法将268例PCOS不孕患者随机分为治疗组和对照组,治疗组腹腔镜术后应用自拟养精种子汤口服。对照组腹腔镜术后辅助来曲唑促排卵治疗。观测两组患者治疗前后睾酮(T)、促卵泡生成素(FSH)、促黄体生成素(LH)、雌激素(E2)及LH/FSH变化,同时观察排卵率、妊娠率、不良反应情况。结果两组患者治疗1个疗程后,LH、LH/FSH、T水平均明显下降,与本组治疗前比较差异有统计学意义(P<0.01);术后6个月治疗组性激素水平仍保持治疗1个疗程后水平,而对照组LH、LH/FSH、T水平上升,基本恢复治疗前水平。治疗组的排卵及妊娠率均明显优于对照组(P<0.05),两组患者流产率比较无明显差异,各组患者均未出现多胎及卵巢过度刺激综合征(OHSS)。结论腹腔镜术后联合养精种子汤口服能有效调节难治性PCOS患者的性激素水平,结合了中西医治疗的优势,值得临床广泛推广应用。
Objective To observe the clinical efficacy on intractable polycystic ovarian syndrome （PCOS） treated with the combined therapy and laparoscopic ovarian drilling （LOD）and self- prepared Yangjing Zhongzi Decoction and ovulation induction with Letrozole （LE）. Methods Two hundred and sixty - eight cases of PCOS were randomized into a treatment and a control group. In the treatment group, the self - prepared Yangjing Zhongzi Decoction was prescribed after LOD. In the control group, the ovulation induc- tion with LE was assisted after LOD. The changes in T, FSH, LH E2 and LH/FSH were observed before and after treatment in the patients of the two groups. The ovulatory rate, pregnancy rate and adverse reactions were observed. Results After 1 session of treatment in the two groups,the levels of LH, LH/FSH and T were re- duced apparently, indicating the significant difference as compared with those before treatment（ P 〈 0.01 ）. In 6 months after LOD, the sexual hormone was remained as that after 1 session treatment in the treatment group. But, the levels of LH, LH/FSH and T were increased and back to those before treatment. The ovulatory rate and pregnancy rate were better apparently in the treatment than those in the control group （ P 〈 0.05 ）. The miscarriage rate was not different in comparison between the two groups. The multiplets and OHSS did not happened in each group. Conclusion The combined therapy of LOD and oral administration of Yangjing Zhongzi Decoction effectively regulates sexual hormone levels in the patients of intractable PCOS. This thera- py integrates the advantages of Chinese and western medicine and deserves to be promote extensively in clini- cal practice.
出处
《世界中西医结合杂志》
2014年第4期389-391,394,共4页
World Journal of Integrated Traditional and Western Medicine
基金
河北省衡水市科学技术研究与发展计划项目(No.12031A)
