摘要
CAL-101是磷脂酰肌醇-3-激酶(PI3K)的高选择性抑制剂,通过直接促进凋亡或抑制微环境中的相互作用对抗肿瘤细胞的生存、增殖及迁移。PI3Kδ的催化亚基P110δ主要在B细胞、T细胞等造血系统表达,现就CAL-101的作用靶点,作用机制,及其在恶性血液病中的应用及前景做一综述。
CAL-101 is a selective inhibitor of the phosphatidylinositol-3 kinase （PI3K）, it inhibits the survival, proliferation and migration of tumor cells by directly inducing apoptosis and inhibiting micro-environmental interactions. It has been determined that the P110δ isoforms of PI3K expressed primarily in cells of hematopoietic lineage, such as B and T cells. This review focuses on the target, mechanism of action, the use and prospect of CAL-101 in tumors of blood and lymph systems.
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2014年第2期530-533,共4页
Journal of Experimental Hematology
