摘要
目的：探讨肿瘤坏死因子-α（tumornecrosisfactor-α，TN－α）基因308位点多态性与乳腺癌易感性的关系。方法：通过检索万方、维普、Medline、CNKI、PubMed和SpringerLink数据库，获取1990—01—2013-05关于TNF-α-308基因多态性与女性乳腺癌遗传易感性关系的研究结果，以乳腺癌组与对照组人群基因型分布的OR值为效应指标，采用STATAll进行Meta分析及检验，并根据一致性检验的结果选用合适的模型（固定效应模型或随机效应模型）进行数据的合并。使用漏斗图来进行发表偏倚的评估，使用Egger’s检验行发表偏倚的检验。结果：Meta分析共纳入16篇文献，累计24548例患者，包括10795例肿瘤患者和13753例对照，G等位基因相对于A等位基因合并0R值为1．12，95％cI为1．07～1．16，P〈0．001。亚组分析中欧美洲人G等位基因相对于A等位基因0R值为1．15，95％CI为1．10～1．20，P〈0．001，亚洲人G等位基因相对于A等位基因0R值为0．86，95％CI为0．66～1．11，P〈0．001，非洲人G等位基因相对于A等住基因0R值为0．64，95％CI为0．52～0．81，P〈0．001。结论：TNFα-308等位基因提高了乳腺癌易感性尤其是对欧美洲人，但对亚洲人来说没有明显关联性，对非洲人来说却能够降低乳腺癌的易感性。
OBJECTIVE： To study the relationship of genetic polymorphism of TNF-α -308 and breast cancer risk. METHODS： All the published studies about TNF-α-308 and breast cancer from 1990-01 to 2013-05 were reviewed and standard techniques of recta-analysis was used in the results of these studies to estimate the significance of the expression of TNF-α-308 more precisely. Meta-analysis odds ratios （ORs） were estimated using a fixed effects model or random effects model RESULTS： Sixteen eligible reports were identified, concerning 10 795 cancer cases and 13 753 controls. The pooled OR of G allele compared with that of A allele was 1.12 （95%CI： 1.07-1.16, P〈0. 001）. The pooled OR of G allele compared with that of A allele for Caucasian was 1.15（95%CI： 1.10-1.20, P〈0. 001）. The pooled OR of G allele compared with that of A allele for Asian was 0.86 （95%CI： 0. 66-1.11, P〈0. 001）. The pooled OR of G allele compared with that of A allele for African was 0.64（95%CI： 0. 52-0. 81, P〈0. 001）. CONCLUSIONS： This meta-anal- ysis suggests that the TNFα -308 G allele is a risk factor for developing breast cancer, especially for Caucasian. TNFα-308 G allele may not be significantly associated with Asian. However, G allele was associated with a decreased risk of breast cancer in African. Further studies are needed to explore gene-gene and gene-environment interactions.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2014年第8期630-634,共5页
Chinese Journal of Cancer Prevention and Treatment
基金
国家自然科学基金(81173601
30973932)
滨州市科技发展计划(2013ZC1708)
