摘要
目的：探讨乳腺浸润性导管癌（invasive ductal carcinoma，IDc）中成纤维细胞生长因子受体1（fibroblast growth factor receptor1，FGFRl）和乳腺癌扩增性抗原1（amplified in breast cancer 1，AIBl）的表达，分析两者与乳腺IDC临床特征的关系以及两者的相关性。方法：采用免疫组织化学SP法检测2006—01-01—2011-06-30河北省人民医院100例经病理科医师确诊、临床病例资料完整的乳腺IDC组织石蜡标本中FGFRl及AIBl的表达情况，分析两者与临床病理特征的关系及两者的相关性。统计所有数据均采用SPSS17．0统计软件进行分析，采用Y。检验或Fisher确切概率法对同一指标的不同临床病理特征进行比较，应用多因素Logistic回归分析FGFRl及AIBl阳性表达有关的因素，采用Spearman等级相关分析乳腺IDC中FGFRl和AIBl表达的相互关系。结果：FGFRl在乳腺IDC中的阳性表达率为31．oo％，其表达与腋窝淋巴结转移（42．86％珊22．41％）、病理组织学分级（Ⅰ级0，Ⅱ级26．80％，Ⅲ级51．60％）和临床分期（Ⅰ期11．10％，Ⅱ期29．40％，Ⅲ期65．00％）有关，差异均有统计学意义，X^2值分别为4．760、12．463和15．671，P值分别为0．029、0．002和〈0．001；AIBl在乳腺IDC中的阳性表达率为75．00％，与腋窝淋巴结转移与否（83．33％79S68．97％）有关，差异有统计学意义（X^2=4．433，P-0．035），其表达随着病理组织学分级（Ⅰ级38．46％，Ⅱ级75．0。％，Ⅲ级90．32％）和临床分期（Ⅰ期44．44％，Ⅱ期84．31％，Ⅲ～Ⅳ期95．OO％）的增高而逐渐增高，差异均有统计学意义（X^2=13．138，P-0．001；x。=20．336，P〈0．001）；多因素Logistic回归分析显示，组织学分级是影响FGFRl及AIBl阳性表达的最主要因素（wald X^2=13．448，P=0．003；wald X^2=7．958，P一0．001）。FGFRl与AIBl表达在乳腺IDC中呈正相关，r-0．237，P-0．017。结论：FGFRl及AIBl与乳腺IDC的淋巴结转移、病理组织学分级及临床分期有关，提示两者与乳腺IDC的发生和发展密切相关，且两者表达呈正相关，联合检测两者可能对乳腺ID2的预后判断更有价值。
OBJECTIVE： To investigate the correlation between the protein expressions of fibroblast growth factor receptorl（FGFR1） and amplified in breast cancer 1 （AIB1） in invasive ductal carcinoma （IDC） of breast and the associa- tions with clinical features. METHODS： S-P Immunohistochemical techniques were adopted to detect the expression of FGFR1 and AIB1 in 100 cases of IDC who were collected from 2006-01-01 to 2011-06-30 in Hebei General Hospital, and had been confirmed by histopathology, with the complete clinical data. SPSS 17.0 statistical software was used for statis- tical analysis. X2 test or Fisher exact Test was used to compare different clinical pathological features of the same parame- ter. Logistic regression analysis was applied for the analysis of positive expression-related factors of FGFR1 and AIB1. Spearman rank correlation was used to analyse the interrelation of FGFR1 and AIB1 in IDC. RESULTS： The positive ex- pression rate of FGFR1 in IDC tissues was 31.00%. The expression of FGFR1 was positively related to the lymph node metastasis（42.86% vs 22.41%）, histological grade（ Ⅰ grade 0, Ⅱ grade 26.80%, Ⅲ grade 51.60%）, clinical stage（Ⅰ staging 11.10 %, Ⅱ staging 29.40 %, Ⅲ-- IV staging 65.00 % ）, with statistical significance （X^2 = 4. 760, P = 0. 029 ; Xz = 12. 463, P= 0. 002; X2= 15. 671, P〈0. 001, respectively）. The positive expression rate of AIB1 in IDC tissues was 75.00%. The positive expression rate of AIB1 in lymph node positive group was significantly higher than that in lymph node negetive group （83.33 % vs 68.970, X^2 = 4. 433, P = 0. 035）, and increased along with the histologic grading （ Ⅰ grade 38.46 %, Ⅱ grade 75.00 %, Ⅲ grade 90.32 % ） and clinical stage（ Ⅰ staging 44.44 %, Ⅱ staging 84.31%, Ⅲ -- Ⅳ stag- ing 95.00%）, the positive expression rate of FGFR1 increased gradually, and the difference was statistically significant （X^2 = 13. 138, P= 0. 001 ; z = 20. 336, P〈0. 001, respectively）. Logistic regression analysis showed that the histological grade of IDC was the main factor impacting the expression of FGFR1 and AIB1 （wald X^2 = 13. 448, P=0. 003; wald .X^2 = 7. 958, P=0. 001）. FGFR1 expression had a positive correlation with the expression of AIB1 （r=0. 237,P=0. 017）. CONCLUSIONS： The expression of FGFR1 and AIB1 have close correlation with lymph node metastasis, histological grade, clinical stage,which present that both proteins have relationship with ocurrance and progress of IDC. FGFR1 is positively related to AIB1 in IDC,and combined detection of them may be valuable for evaluating the prognosis of IDC.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2014年第8期594-598,共5页
Chinese Journal of Cancer Prevention and Treatment
基金
河北省科技支撑计划(11276103D-70)
关键词
乳腺肿瘤
浸润性导管癌
FGFR1
AIB1
免疫组织化学
预后
breast neoplasms
invasive ductal carcinoma
fibroblast growth factor receptorl
amplified in breast canc-er 1
immunohistochemistry
prognosis
