摘要
目的 观察放置左炔诺孕酮宫内缓释系统（LNG-IUS）联合散结镇痛胶囊、氨甲环酸片治疗子宫腺肌病的临床效果。方法 2010年7月—2012年4月，选取我院确诊子宫腺肌病病人88例，分为A组（放置LNG-IUS并遵医嘱口服散结镇痛胶囊及氨甲环酸片治疗）35例，B组（放置LNG-IUS）28例，C组（口服散结镇痛胶囊及氨甲环酸片）25例。比较3组治疗后1、2、3、6、12个月时的痛经评分；6、12个月时子宫体积变化；12个月时月经过多者血红蛋白值及外周血CA-125变化。观察置环后阴道点滴出血等并发症发生情况。结果 A组1、2、3、6个月时痛经评分较其他两组低，差异有统计学意义（F=4.648～32.009，P〈0.05）；12个月时A组和B组痛经评分差异无统计学意义，但均较C组显著降低（F=43.721，P〈0.05）。6、12个月时A、B组子宫体积较治疗前显著缩小（t=4.756-8.642，P〈0.05），C组与治疗前比较差异无统计学意义（P〉0.05）。12个月时3组中重度贫血病人血红蛋白水平均较治疗前显著升高（t=13.309-70.578，P〈0.05）。12个月时A、B组血CA-125浓度较治疗前显著降低（t=6.380、6.710，P〈0.05），C组与治疗前比较差异无统计学意义（P0.05）。A、B组均有病人出现阴道点滴出血，但A组口服氨甲环酸片止血效果明显。结论 放置LNG-IUS联合散结镇痛胶囊、氨甲环酸片可短时间内缓解痛经并有效治疗月经量过多的子宫腺肌病。
Objective To evaluate the effects of combined levonorgestrel-releasing intrauterine system （LNG-IUS） with Sanjie Zhentong Capsules （SZC） and Tranexamic Acid Tablets （TAT） for adenomyosis. Methods During July 2010—April 2012, 88 patients confirmed with adenomyosis were divided into three groups in random： group A （35 patients）, the patients were placed with LNG-IUS, and took SZC and TAT according to the instructions; group B （28）, a LNG-IUS was placed; group C （25）, took SZC and TAT. A dysmenorrhea score was compared between the three groups after 1-,2-, 3-, 6-and 12-month therapy; uterine volume changes after 6-and 12-month therapy were observed, and hemoglobin and CA-125 levels in those with menorrhagia after 12-month therapy was detected. Complications, such as vaginal spotting, after LNG-IUS placement, were observed. Results The dysmenorrhea score of group A at previous 6 months of treatment was lower than the other two groups （F=4.648-32.009,P〈0.05）, at month 12, the difference of the score was not significant between groups A and B, but markedly lower than group C （F=43.721,P〈0.05）. At months 6 and 12, the volume of body of uterus in groups A and B was dramatically decreased compared with before therapy （t=4.756-8.642,P〈0.05）, that in group C, the difference was not significant compared with before therapy （P〉0.05）. Hemoglobin of the patients with moderate to severe anemia in the three groups increased at month 12 after medication, the levels of CA-125 in groups A and B declined （t=6.380,6.710;P〈0.05）, and that in group C was not significantly different （P〉0.05）. Vaginal spotting was observed in patients in the groups A and B. Dramatic efficacy was obtained in group A with oral TAT medication.
Conclusion Placing LNG-IUS combined with SZC and TAT can relieve dysmenorrhea in a short time and effectively treat adenomyosis with menorrhagia.
出处
《齐鲁医学杂志》
2014年第2期132-134,136,共4页
Medical Journal of Qilu
关键词
左炔诺孕酮
药物释放系统
散结镇痛胶囊
氨甲环酸
子宫腺肌病
痛经
levonorgestrel
drug delivery systems
Sanjie Zhentong Capsules
tranexamic acid
adenomyosis
dysmenorrhea
