摘要
目的:观察益气活血解毒法对脓毒症白介素-1β(IL-1β)及氨基末端脑利钠肽前体(NTproBNP)水平的影响。方法:60例随机分为治疗组30例和对照组30例,两组均给予常规西医治疗,治疗组加用参麦注射液、丹参酮ⅡA磺酸钠注射液静滴和热毒清口服液口服或鼻饲,两组疗程均为7天。两组分别于治疗前及治疗7天进行急性生理学与慢性健康状况评分系统(APACHEⅡ)评分,比较血清白介素-1β(IL-1β)和血浆氨基末端脑利钠肽前体(NT-proBNP)的变化及临床疗效。结果:治疗7天后,治疗组和对照组APACHE-Ⅱ分值、IL-1β、NTproBNP水平均改善(P<0.05),治疗组改善更为明显(P<0.05);治疗组总有效率93.3%,对照组总有效率73.3%,两组比较有统计学意义(P<0.05)。结论:在西医治疗基础上用益气活血解毒法治疗脓毒症可抑制炎症因子,改善机体心肌抑制状况,有更好的治疗效果。
Objective To observe the clinical therapeutic effects of qi-boosting blood-quickening detoxicating therapy on Effects of IL-1βand NT-proBNP in patients with sepsis.Methods： 60 cases were diagnosed as sepsis with Qi deficiency and blood stasis heat toxin filled type patients were randomLy divided into the the treatment group （ n =30 ） and the control group （ n=30 ） .The general therapy of the two groups was the same, the treatment group were received Shen Mai injection, Sodium Tanshinone H Asilate injection and Reduqing oral liquid on the basis of the general therapy.Course of treatment was 7 days.Before and after seven days treatment, two groups were estimated separately on Traditional Chinese medical scores and acute physiology and chronic health evaluation 11 （ APACHE-Ⅱ ） , the changes of serum IL-1β , NT-proBNP and the clinical efficacy were compared in both groups.Results： APACHE- Ⅱ scores and the serum IL-1β, NT-proBNP levels in both groups after treatment were improved obviously （ P〈0.05 ） , the treatment group were more apparent （ P〈0.05 ） ; The efficiency was 93.3% in the treatment group and the control group was 73.3%, the two groups have a significant difference （ P〈0.05 ） .Conclusion ： The method of qi-boosting blood-quickening detoxicating have a better therapeutic effect by treating sepsis, inhibiting inflammatory factors and improving myocardial depression status.
出处
《实用中医药杂志》
2014年第5期379-381,共3页
Journal of Practical Traditional Chinese Medicine
