摘要
目的 探讨老年冠心病患者非心脏手术围手术期血液流变学变化规律及与心血管事件的关系。方法 以NXE - 1型椎板粘度计在 15 0 S -1、6 0 S -1和 10 S -13个不同切变条件下测定老年冠心病手术患者的全血粘度、全血还原粘度 ,在中切变条件下测定血浆粘度 ,以常规方法测定血球压积。并以非手术的内科冠心病患者为对照。结果 老年冠心病病患者全血粘度、全血还原粘度在术中及术后 2 4h显著增高 ,72h后逐渐恢复正常 ,血球压积在术后 2 4h增高 ,血浆粘度及在其它时间点的血球压积无显著变化。结论 老年冠心病患者术中及术后血液粘度明显增高 ,其高峰在 2 4h左右 ,72h后有降低趋势 ,这对围手术期心肌缺血和心血管并发症的发生有重要影响。
Objective To explore the change of blood rheological parameters and it’s influence to peri-operative cardiovascular events in peri-operative periods of elderly coronary heart disease patients.Methods With non-surgery elderly CHD patients at the same periods as control,the whole blood viscosity and whole blood reduction viscosity were determined under three different shearing stress conditions (150 S-1 ,60 S-1 and 10 S-1 )by NXE-1 weissenberg wiscosimeter,plasma viscosity was tested under middle shearing stress condition,and the hematocrit was also determined by routine method.Result Whole blood viscosity and whole blood reduction viscosity was significantly increased during intraoperative and 24 hours after surgery,and gradually returned to normal 72 hours after surgery.Hematocrit was in normal range except at the time point of 24 hours after surgery,and plasma viscosity is in normal range in all test time.Conclusions The peak of blood viscosity is at around 24 hours after surgery,and there is a decrease of 72 hours after surgery.Maybe,this is one of the important factor to the mechanism of perioperative ischemia and cardiovascular complications.
出处
《中国急救医学》
CAS
CSCD
北大核心
2001年第3期148-150,共3页
Chinese Journal of Critical Care Medicine
基金
军队九五重点攻关课题! (95Z0 5 4)
关键词
老年人
冠心病
非心脏手术
围手术期
心肌缺血
血液流变学
Elderly
Coronary heart disease
Non-cardiac surgery
Perioperative
Myocardial ischemia
Hemorheological
