摘要
目的 观察妊娠高血压综合征 (妊高征 )患者血清可溶性白细胞介素 6受体 (sIL 6R)和可溶性糖蛋白 (sgp130 )的变化。方法 应用酶联免疫吸附法 (ELISA)检测 40例妊高征患者 (妊高征组 )和 2 0例正常非孕妇女 (对照组I)、2 0例正常妊娠妇女 (对照组II)血清sIL 6R和sgp130水平。结果妊高征组血清sIL 6R为 (196 7± 12 9) μg/L ,sgp130为 (379 4± 79 3) μg/L ;对照组I血清sIL 6R为(174 8± 46 2 ) μg/L ,sgp130为 (2 73 6± 2 8 3) μg/L ;对照组II血清sIL 6R为 (174 4± 48 3) μg/L ,sgp130为 (2 5 4 4± 34 7) μg/L。妊高征组血清sIL 6R和sgp130水平均高于对照组I和对照组II,差异有极显著性 (P <0 0 1)。妊高征组中 ,随病情加重 ,血清sIL 6R、sgp130水平逐渐升高。差异有极显著性 (P<0 0 1)。对照组II血清sIL 6R和sgp130水平与对照组I比较 ,差异无显著性 (P >0 0 5 )。结论 血清sIL
Objective To observe the changes of serum soluble interleukin 6 receptor (sIL 6R) and soluble gp130 (sgp130) in patients with pregnancy induced hypertension. Methods Enzyme linked immunosorbent assay (ELISA) was used to determine serum sIL 6R and sgp130 levels in 40 patients with pregnancy induced hypertension (study group), 20 normal non pregnant women (control group I) and 20 normal pregnant women (control group II). Results In study group, sIL 6R was (196 7±12 9) μg/L and sgp130 was (379 4±79 3) μg/L. In control group I, sIL 6R was (174 8±46 2) μg/L and sgp130 was (273 6±28 3) μg/L. In control group II, sIL 6R was (174 4±48 3) μg/L and sgp130 was (254 4±34 7) μg/L. SIL 6R and sgp 130 were higher in study group than those in control groups with significant difference ( P <0 01). In study group, the more severe the patients, the higher the sIL 6R and sgp130 levels. There was significant difference ( P <0 01). There was no difference in sIL 6R and sgp130 levels between control groups ( P >0 05). Conclusions Serum sIL 6R and sgp130 levels are related to the development of pregnancy induced hypertension.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2001年第1期18-19,共2页
Chinese Journal of Obstetrics and Gynecology
