摘要
目的 :研究复发性中高度非霍奇金淋巴瘤的解救治疗。方法 :将 2 4例复发性中高度非霍奇金淋巴瘤分成 2组 :有不利因素组 10例 ,无不利因素组 14例。以异环磷酰胺、米托蒽醌、平阳霉素、强的松组成IMPP方案联合化疗再诱导 ,异环磷酰胺 (IFO) 1.5 m2 溶于生理盐水 10 0 0ml中静滴 4小时 ,第 1— 4天 ,美司钠 (mesna)用量为IFO的 6 0 %于IFO 0、4、8小时静脉冲入。米托蒽醌 (Mx) 8mg m2 溶于生理盐水或糖水 2 5 0ml中静滴 ,第 1天 ;平阳霉素(PYM) 5mg m2 肌注第 8、15天 ;强的松 (Pred) 10 0mg d ,第 1— 5天。 4周为 1疗程 ,连用 2疗程评定疗效。结果 :总CR 5 8.3% (14 2 4) ,RR 79.2 % (19 2 4) ,其中有不利因素组CR 30 % (3 10 ) ,RR 6 0 (6 10 ) ,无不利因素组CR 78.5 %(11 14) ,RR 92 .8% (13 14) ,2组CR、RR均有显著差异 (P <0 .0 1)。毒副反应主要是骨髓抑制、恶心、呕吐、脱发、发热 ,给予G CSF、5 HT3受体拮抗剂 ,对症处理后均能缓解 ,无治疗相关病死率。结论
Purpose:To study the salvage treatment of recurrent intermediate—high grade non Hodgkin lymphoma(NHL). Methods:24 cases of recurrent intermediate—high NHL were divided into two groups: 10 cases with poor prognostic factors in group one(G1), 14 cases without poor prognostic factors in group two(G2).All cases were treated with ifosfamide(IFO), mitoxantrone(Mx), pingyangmycine(PYM), prednisone(Pred) (IMPP). IFO 1.5 g/m 2 iv on days 1 to 4, and mesna iv at hours;0, 4, 8 Mx 8 mg/m 2 on day 1; PYM 5mg/m 2 im on days 8 and 15; and Pred 100mg/d po on days 1 to 5. Every 4 weeks as one cycle. Assessment was given after 2 cycles. Results:The total CR rate was 58.3%(14/24), RR 79.2%(19/24). The CR rate was 30%(3/10), RR 60%(6/10) in G1 and the CR rate was 78.5% (11/14), RR 92.8%(13/14) in G2 ,respeetively. The difference of the two groups in CR and RR was significant( P <0.01). The main toxicity and side effects were myelosuppression,nansea, vomiting, alopecia, fever and these can be controlled by G CSF, 5 HT3 antagonist. There was no death related to treatment. Conclusions:IMPP regimen is a salvage treatment for recurrent intermediate—high grade NHL.
出处
《中国癌症杂志》
CAS
CSCD
2001年第1期59-60,68,共3页
China Oncology
