摘要
目的：寻找与贲门癌发生相关的癌前病变。方法：通过对我国食管癌高发区河北省涉县 186例受检者的内镜普查，在贲门区不同位点（贲门脊根部－内镜下 12°点位和对侧－内镜下 6°点位）取活检，进行病理学检查。对比研究我国食管癌高发区河北省涉县居民贲门区粘膜的不同位点上贲门癌发生的差异和癌前病变的差异。进行分组χ 2检验， P< 0.05有显著差异。结果：检出贲门癌 11例。 10例发生在贲门脊根部－内镜下 12°点位占 90.9％， 1例发生在对侧－内镜下 6°点位占 9.01％。贲门区粘膜的不同位点上癌前病变的类型相同，都可为慢性浅表性胃炎、慢性胃炎、慢性活动性胃炎和慢性萎缩性胃炎以及肠化、萎缩和不典型增生；但慢性活动性胃炎在 12°点位检出率明显高于 6°点位， P< 0.05，与贲门癌的检出位点相一致。结论：我国食管癌高发区居民贲门区粘膜的不同位点上癌及癌前病变存在差异；慢性活动性胃炎可能与贲门癌的发生有密切关系。
Objective： This study was designed to investigate and find out which of the precancerous lesions at gastric cardia are closely related to carcinoma.Methods： A total of 186 patients were examined by endoscopy, and took biopsy specimen from different sites of gastric cardia(clock 12° and clock 6° respectively in endoscopy). All specimens were detected through normal pathological process. Then statistical analysis was performed. Result： The same precancerous lesions were found at sites of 12° and 6° , they were superficial gastritis, chronic gastritis, chronic active gastrits, intestinal metaplasia, and atypical hyperplasia etc. The most chronic active gastritis were at sites of 12° (P< 0.05). Meanwhile, 11 patients with carcinoma of gastric cardia were also found, 10 of them(90.9％ ) were located in site of 12° , 1 (9.01％ ) in site of 6° . Conclusion： The chronic active gastritis at the site of 12° may be closely related to the occurrence of carcinoma of gastric cardia.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2001年第3期317-319,共3页
Chinese Journal of Cancer
关键词
贲门肿瘤
癌前病变
位点
： Gastric cardiac cancer
Precancerous lesion
Site
